Somarant(Suvorexant)

Therapeutic Group: Drugs of Nervous System

Presentation

Somarant tablet: Each tablet contains Suvorexant INN 10 mg.

Description

Suvorexant a highly selective antagonist for orexin receptors OX1R and OX2R. The mechanism by which Suvorexant exerts its therapeutic effect in insomnia is presumed to be through antagonism of orexin receptors. The orexin neuropeptide signaling system is a central promoter of wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive.

Indications

Somarant is indicated for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance.

Dosage & Administration

Use the lowest dose effective for the patient .
Recommended dose is 10 mg, no more than once per nighttaken before 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be increased, not to exceed 20 mg once daily.
Time to effect may be delayed if taken with or soon after a meal.

Side Effects

sleepiness during the day
- not thinking clearly
- act strangely, confused, or upset
- sleep-walking

Precautions

Daytime somnolence: Risk of impaired alertness and motor coordination, including impaired driving; risk increases with dose; caution patients taking 20 mg against next-day driving and other activities requiring complete mental alertness.
Need to evaluate for co-morbid diagnoses: Reevaluate if insomnia persists after 7 to 10 days of treatment.

Use in Pregnancy & Lactation

Pregnancy Category C
There are no adequate and well-controlled studies in pregnant women. Somarant should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.