Revert(Cinnarizine-Dimenhydrinate )

Therapeutic Group: Drugs of Nervous System


Revert tablet: Each tablet contains 20 mg cinnarizine and 40 mg dimenhydrinate.


Revert consists of two compounds: cinnarizine and dimenhydrinate. Dimenhydrinate, the chlorotheophylline salt of diphenhydramine, acts as antihistamine with anticholinergic properties. The substance exhibits anti-emetic and antivertiginous effects through influencing the chemoreceptor trigger zone in the region of the 4th ventricle. Cinnarizine acts mainly as a vestibular sedative through inhibition of the calcium influx into the vestibular sensory cells. Cinnarizine thus acts predominantly on the peripheral vestibular system. The combination product is more effective than the individual compounds.


Revert is indicated for the treatment of vertigo symptoms of various origins.

Dosage & Administration

Adults: 1 tablet three times daily, to be taken unchewed with some liquid after meals.

Children and adolescents under the age of 18 years: Revert is not recommended in children and adolescents under the age of 18 years because there are no data available on the use of Revert in this age group.

Elderly: Dosage as for adults.
In general, the duration of treatment should not exceed four weeks. The physician shall decide whether longer treatment is required.

Side Effects

The most frequently occurring side-effects are somnolence and dry mouth. These reactions are usually mild and disappear within a few days even if treatment is continued. In addition the following adverse reactions are associated with dimenhydrinate and cinnarizine:
Dimenhydrinate: paradoxical excitability (especially in children), worsening of an existing angleclosure glaucoma and reversible agranulocytosis.
Cinnarizine: constipation, weight gain, tightness of the chest, cholestatic jaundice, extrapyramidal symptoms, lupus-like skin reactions, lichen planus.



Use in Pregnancy & Lactation

Pregnancy: The safety of Revert in human pregnancy has not been established.
Lactation: Dimenhydrinate and cinnarizine are excreted in human breast milk. Revert should not be taken by women who are breast feeding.