Mecolagin(Mecobalamin)

Therapeutic Group: Drugs of Nervous System

Presentation

Mecolagin® Chewable Tablet: Each tablet contains Mecobalamin INN 0.5 mg.

Mecolagin® Injection: Each 1 ml ampoule contains sterile Mecobalamin INN 500mcg.

Description

Mecobalamin is the one and only homologue of vitamin B12, found in the brain that participates in transmethylation as a B12 containing co-enzyme. It plays a fundamental role in protein synthesis and stimulates methionine synthesis from homocysteine and helps to restore normal levels of DNA and RNAs in nerve cells. It also enhances the formation of lecithin (another major component of the myelin sheath).

Indications

• Peripheral Neuropathies

• Diabetic Neuropathy

• Verteberal Syndrome

• Nerve Compression Syndrome

• Multiple sclerosis

• Amyotrophic lateral sclerosis

• Parkinson’s disease

• Alzheimer’s disease

• Diabetic retinopathy

• Entrapment neuropathy

• Drug induced neuropathy

• Megaloblastic anemia due to Vitamin B12 deficiency

Dosage & Administration

Tablet :The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.
Injection :Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecobalamin, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecobalamin every one to three months as maintenance therapy

Side Effects

Generally Mecobalamin is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecobalamin.

Precautions

N/A

Use in Pregnancy & Lactation

Not recommended during pregnancy & lactation.

Use in children
Not recommended for children.