
Hopetavir: Each tablet contains Sofosbuvir INN 400 mg




- Sofosbuvir efficacy has been established in subjects with HCV genotype 1, 2, 3 or 4 infection, including those with hepatocellular carcinoma meeting Milan criteria (awaiting liver transplantation) and those with HCV/HIV-1 co-infection


- Should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC.
Recommended combination therapy:
(HCV Mono-infected and HCV/HIV-1 Co-infected )
Genotype 1 or 4 :Sofosbuvir + Peginterferon alfa + Ribavirin for 12 weeks
Genotype 2:Sofosbuvir + Ribavirin for 12 weeks
Genotype 3: Sofosbuvir + Ribavirin for 24 weeks
- Sofosbuvir in combination with Ribavirin for 24 weeks can be considered for CHC patients with genotype 1 infection who are Interferon ineligible
- Should be used in combination with Ribavirin for treatment of CHC in patients with hepatocellular carcinoma awaiting liver transplantation for up to 48 weeks or until liver transplantation whichever occurs first
- A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease








Extreme caution must be taken to avoid pregnancy in female patients and female partners of male patients while taking this combination. Women of childbearing potential and their male partners should not receive Ribavirin unless they are using two forms of effective contraception during treatment with Ribavirin and for 6 months after treatment has concluded.
Pregnancy Category B: Sofosbuvir monotherapy
There are no adequate and well-controlled studies with Sofosbuvir in pregnant women.
Lactation: It is not known whether Sofosbuvir and its metabolites are present in human breast milk. Because of the potential for adverse reactions from the drug in nursing infants, a decision must be made whether to discontinue nursing or discontinue treatment with Ribavirin-containing regimens, taking into account the importance of the therapy to the mother.
We can say that a-line wedding dresses are a kind of classic dress model. It has been so popular from time to time. Therefore, people know it as a timeless dress cut for bridal. As like its name, the A-line dress is intentionally designed to follow the A Letter shape. It is different with ball gown. The A-line dress has softer silhouette to hide your big bottom with its flared skirt cut. Commonly, the most matching top cut which is usually applied on the A-line dress is fit waist line cut. It is a waist cut which emphasizes your slim waist shape perfectly.
Pediatric Use:
Safety and effectiveness of Sofosbuvir in children less than 18 years of age have not been established.




Hopetavir Container Pack: Each container contains 28 tablets