Celbarin: Each capsule contains Ribavirin BP 200 mg.
Ribavirin + Interferon
Genotype Ribavirin Daily Interferon alpha-2a Duration or interferon alpha-2b
All < 75 kg=(400+600) mg 3 MIU 3 times weekly 48 weeks Genotypes subcutaneously (Genotype1&4)
> 75 kg=(600+600) mg 24 weeks
Ribavirin + Peg-Interferon
Genotype Ribavirin Daily Peg-Interferon alpha-2a Duration or Peg-interferon alpha-2b
1 & 4 < 75 kg=(400+600) mg 180 �gm once weekly 48 weeks > 75 kg=(600+600) mg subcutaneously
2 & 3 (400+400) mg 24 weeks
Ribavirin may be administered without regard to food, but should be administered in a consistent manner. Drink plenty of water while being treated with this medication; drinking water will decrease the risk of serious side effects.
Contraindications: Ribavirin is contraindicated in patients with known hypersensitivity to Ribavirin or any components of the capsule, women who are pregnant, men whose female partners are pregnant, patients with hemoglobinopathies (e.g. thalassemia major or sickle cell anemia), autoimmune hepatitis or hepatic decompensation before or during treatment. No pharmacokinetic interactions were noted between peg-interferon alpha and Ribavirin.
Precautions: Before using this medicine, consult your doctor if you have: severe heart disease, kidney disease, blood disorders (e.g. sickle cell anemia, low hemoglobin), other types of hepatitis (e.g. autoimmune hepatitis), other liver problems, heart problems, breathing problems, pancreas problems (e.g. pancreatitis), diabetes, any allergies. Use caution engaging in activities requiring alertness such as driving or using machinery. Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.
Pregnancy and lactation: This medication must not be used during pregnancy. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended.
Pediatric patients: Safety and efficacy of Ribavirin has not been established in patients below the age of 18 yrs.