Alestor: Each tablet contains Allylestrenol INN 5mg.
Allylestrenol is an orally active gestagen. Allylestrenol has a pronounced pregnancy maintaining action in castrated animals without producing hormonal side-effects. In the human, premature termination of pregnancy often follows a fall in the levels of placental hormones. Alestor has been shown to stimulate the placental progesterone production in vitro & to promote the secretion of placental hormones (human chorionic gonadotrophin, human placental lactogen, oestrogens and progesterone) and oxytocinase in patients with pregnancy at risk. In aggrement to this the trophoblastic layers of the placenta show histological signs of activation. Clinical studies have indicated that Alestor is an effective & safe pregnancy preparation. Administration of Alestor in combination with bed rest can remove or prevent the threat of abortion in early pregnancy or stop threatened premature labor.
Alestor is indicated for -
- Intra uterine Growth Retardation (IUGR)
- Threatened abortion
- Habitual abortion
- Threatened premature labor
- Failure of nidation
Alestor should be taken orally. The dose of the drug depends on the indication.
Intra Uterine Growth Retardation [IUGR]: 1 tablet three times a day at least two months. Reduce the dose if symptoms improve.
Threatened Abortion: 1 tablet thrice daily for 5-7 days. The treatment period may be extended depending on necessity. After symptoms disappear, the dosage should be gradually reduced.
Habitual Abortion: 1 to 2 tablets daily with the confirmation of pregnancy. Administration should be continued until at least one month after the critical period.
Threatened Premature Labour: 40 mg daily until symptoms improve.
Failure of Nidation: 2 - 4 tablets daily from 16th to 26th day of the cycle until conception is achieved.
Gastrointestinal complaints like nausea, vomiting etc. have been reported.
No precautions are applicable.
Allylestrenol is extremely safe. Serious adverse reactions have neither been reported in mother. It is free from anti-ovulatory and androgenic properties. Allylestrenol produces no masculinization of female foetus.