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Xenogrow (Minoxidil)
Therapeutic Group: Skin » Hair Growth Promoter
Presentation

XENOGROW 2%: Each mL solution contains Minoxidil USP 20 mg

XENOGROW 5%: Each mL solution contains Minoxidil USP 50 mg.

Descriptions
Minoxidil can reverse the hair loss process of androgenetic alopecia by the following means: increase the diameter of hair shaft; stimulate anagen growth; prolong the anagen phase; stimulate anagen recovery from telogen phase.

As a peripheral vasodilator Minoxidil enhances microcirculation of hair follicles. The Vascular Endothelial growth factor (VEGF) is stimulated by Minoxidil and VEGF is presumably responsible for the increased capillary fenestration, indicative of a metabolic activity observed during the anagen phase.
Indications
Minoxidil indicated for the treatment of alopecia androgenetica in men and women aged between 18 and 65.
Dosage & Administration
Hair and scalp should be thoroughly dry prior to topical application of Minoxidil. A dose of 1 ml Minoxidil cutaneous solution should be applied to the total affected areas of the scalp twice daily. The total dosage should not exceed 2 ml. If fingertips are used to facilitate drug application, hands should be washed afterwards.
It should be used twice daily for four months or more before evidence of hair growth can be expected.
Side Effects
Minoxidil is well tolerated. However few side effects such as hypertrichosis (unwanted non-scalp hair including facial hair growth in women), local erythema, itching, dry skin/scalp flaking, and exacerbation of hair loss have been reported commonly.
Precautions
Before using Minoxidil, the user should determine that the scalp is normal and healthy. Patients with known cardiovascular disease or cardiac arrhythmia should contact a physician before using Minoxidil. Minoxidil contains alcohol, which will cause burning and irritation of the eye. In the event of accidental contact with sensitive surfaces (eye, abraded skin and mucous membranes) the area should be bathed with large amount of cool tap water.
Contraindications
Minoxidil topical solution is contraindicated in patients with a history of hypersensitivity to Minoxidil or any of the other ingredients in the formulation such as propylene glycol or ethanol.
Use in Pregnancy & Lactation
Pregnancy: Studies in animals have shown reproductive toxicity. The potential risk for humans is unknown. Minoxidil should not be used during pregnancy.
Lactation: It is recommended that breast-feeding should be discontinued during treatment with Minoxidil.
Drug Interaction
Topical drugs, such as corticosteroids, tretinoin, dithranol or petrolatum which alter the stratum corneum barrier, could result in increased absorption of Minoxidil if applied concurrently. Although it has not been demonstrated clinically, there exists the theoretical possibility of absorbed minoxidil potentiating orthostatic hypotension caused by peripheral vasodilators.
Overdose
Increased systemic absorption of Minoxidil may potentially occur if higher-than-recommended doses of Minoxidil are applied to larger surface areas of the body or areas other than the scalp. There are no known cases of Minoxidil overdosage resulting from topical administration of Minoxidil.
Signs and symptoms of Minoxidil overdosage would primarily be cardiovascular effects associated with sodium and water retention, and tachycardia. Fluid retention can be managed with appropriate diuretic therapy. Clinically significant tachycardia can be controlled by administration of a beta-adrenergic blocking agent.
Commercial Packaging
Xenogrow 2%: Each bottle contains 60 ml solution of Minoxidil USP 2%.
Xenogrow 5%: Each bottle contains 60 ml solution of Minoxidil USP 5%.
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