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Omidon (Domperidone)
Therapeutic Group: Gastro Intestinal Disorders » Prokinetic-Antiemetic
Presentation

Omidon Tablet: Each film coated white, circular tablet contains Domperidone Maleate BP equivalent to 10 mg Domperidone.

Omidon D Tablet : Each dispersible tablet contains Domperidone BP 10 mg.

Omidon Suspension : Whitish, lemon flavoured each 5 ml contains 5 mg of Domperidone.

Omidon Paediatric drops : Each ml contains 5 mg of Domperidone.

Descriptions
Omidon is a Dopamine antagonist .Because it does not readily enter the central nervous system, its effects are confined to the periphery and acts principally at the receptor in the chemoreceptor trigger zone.
Indications
1. Stimulation of gut mobility

a) Non-ulcer dyspepsia

b) Esophageal reflux, reflux esophagitis and gastritis

c) Diabetic gastroparesis

d) Functional dyspepsia

e) Speeding barium transit in \\\'follow-through\\\' radiological studies

2. Prevention and symptomatic relief of acute nausea and vomiting from any cause

including cytotoxic therapy, radio therapy and anti-parkinsonism therapy

3. In the treatment of migraine.
Dosage & Administration
The recommended oral dose for
Adults : 10 - 20 mg every 4 - 8 hours daily
Children : 0.2 - 0.4 mg/kg every 4 - 8 hours daily.
Note : Omidon tablet and suspension should be taken 15 - 30 minutes before a meal.
For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Side Effects
Domperidone may produce hyperprolactinemia(1.3% frequency). This may result in galactorrhea, breast enlargement and soreness and reduced libido. Dry mouth (1.9%), thirst, headache (1.2%), nervousness, drowsiness (0.4%), diarrhea (0.2%), skin rash and itching (0.1%) may occur during treatment with Domperidome. Extra-pyramidal reactions are seen in 0.05% of patients in clinical studies.
Precautions
Domperidone should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood-brain barrier.
Contraindications
Domperidone is contraindicated to patients who have known hypersensitivity to this drug and in case of neonates.
Use in Pregnancy & Lactation
Pregnant women : The safety of Domperidone has not been proven and it is therefore not recommended during pregnancy.Animal studies have not demonstrated teratogenic effects on the fetus.
Lactating mother : Domperidone may precipitate galactorrhea and improve post-natal lactation. It is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Drug Interaction
Domperidone may reduce the hypoprolactinemic effect of bromocriptine. The action of Domperidone on GI function may be antagonized by anti-muscarinics and opioid analgesics.
Overdose
There are no reported cases of overdosage.
Commercial Packaging
Omidon Tablet : Each box contains 10 blister strips of 10 tablets.
Omidon D Tablet : Each box contains 10 blister strips of 10 tablets.
Omidon Suspension : Each bottle contains 100 ml of suspension.
Omidon Suspension : Each bottle contains 60 ml of suspension.
Omidon Paediatric drops : Each bottle contains 15 ml of paediatric suspension.
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Omidon
Domperidone tablet/dispersible tablet/suspension/paediatric drops
 
 

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