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Neocilor (Desloratadine)
Therapeutic Group: Anti Histamine
Presentation

Neocilor tablet: Each film-coated tablet contains Desloratadine INN 5 mg.

Neocilor syrup: Each 5 ml syrup contains Desloratadine INN 2.5 mg.

Descriptions
Neocilor is a preparation of Desloratadine. Desloratadine is a long-acting tricyclic histamine antagonist with selective H1-receptor antagonist activity. It is a non-sedating antihistamine. Desloratadine has effects on the chronic inflammatory response to allergens and lacks effects on the QT interval of ECG, unlike some other non-sedating antihistamines.
Indications
Allergic rhinitis: Neocilor is indicated for the relief of nasal and non-nasal symptoms of allergic rhinitis (seasonal and perennial).

Chronic idiopathic urticaria: Neocilor is indicated for the symptomatic relief of pruritus, reduction in the number of hives and size of hives, in patients with chronic idiopathic urticaria.

Dosage & Administration
As there are no food effects on the bioavailability, Neocilor may be taken without regard to meal.
Adults and adolescent of 12 years or over : 5 mg once daily.
Child 6-11 years : 2.5 mg once daily.
Child 12 months-5 years : 1.25 mg (2.5 ml Neocilor syrup) once daily.
Child 6 months-11 months : 1 mg (2 ml Neocilor syrup) once daily.
Patients with liver or renal impairment: A starting dose of one Neocilor tablet (Desloratadine 5 mg) every other day is recommended.
Pediatric use: The safety and effectiveness of Desloratadine in pediatric patients under 6 months of age has not been established.
Side Effects
Desloratadine is generally well tolerated. However, dry mouth, fatigue, somnolence and myalgia are commonly reported side-effects. Less common side-effects may include dizziness, headache and nausea. Rarely rash, pruritus and urticaria may occur.
Contraindications
Neocilor is contraindicated in patients who are hypersensitive to this medication or to any of its ingredients or to Loratadine.
Use in Pregnancy & Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, Desloratadine should be used in pregnancy only if clearly needed.
Lactation: Desloratadine passes into breast milk. Therefore, a decision should be made whether to discontinue nursing or to discontinue Desloratadine, taking into account the importance of the drug to the mother.
Drug Interaction
No clinically important drug interactions have been reported.
Overdose
No clinically relevant adverse events have been reported in case of overdosage. However, in the event of overdosage, symptomatic and supportive treatment is recommended.
Commercial Packaging
Neocilor tablet: Each box contains 10 blister strips of 10 tablets.
Neocilor syrup: Bottle containing 50 ml syrup.

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