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Lopirel (Clopidogrel)
Therapeutic Group: Cardiovascular » Anti Platelet
Presentation
Lopirel

Lopirel Tablet: Each film-coated tablet contains Clopidogrel bisulphate INN equivalent to Clopidogrel 75 mg.

Descriptions
Lopirel (Clopidogrel) is an inhibitor of platelet aggregation. Lopirel (Clopidogrel) selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet receptor and the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation.
Indications
Lopirel (Clopidogrel) is indicated for the reduction of atherosclerotic events (myocardial infarction, ischaemic stroke, and vascular death) in patients with atherosclerosis documented by recent stroke, recent myocardial infarction, or established peripheral arterial disease.
Dosage & Administration
The recommended dose of Lopirel (Clopidogrel) is 75 mg once daily with or without food.
Side Effects
Generally Clopidogrel is well tolerated. However, a few common side effects i.e. Influenza-like symptoms, headache, upper respiratory tract infection, dizziness, muscle and back pain, and rash may occur.
Precautions
As with other anti-platelet agents, Clopidogrel should be used with caution in patients who may be at risk of increased bleeding from trauma, surgery, or other pathological conditions. Clopidogrel should be discontinued 7 days prior to surgery. Clopidogrel should be used with caution in hepatically impaired patients who may have bleeding diatheses.
Contraindications
The use of Clopidogrel is contraindicated in the following conditions:
Hypersensitivity to the drug substance or any component of the product.
Peptic ulcer and intracranial hemorrhage.
Use in Pregnancy & Lactation
Pregnancy: There are no adequate and well-controlled studies of Clopidogrel in pregnant women. However, Clopidogrel should be used during pregnancy only if clearly needed.
Nursing Mother: Clopidogrel is not recommended for use while breast-feeding. It is not known for sure whether Clopidogrel is excreted in breast milk, although it is suspected that it is.

Use in children
Safety and effectiveness of Clopidogrel in pediatric population have not been established.
Overdose
In the event of over dosage no adverse effects were reported and no therapy was substituted.
Commercial Packaging
Lopirel tablet: Each box contains 3 blister strips of 10 tablets.
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