Carbestop injection: Each ml injectable solution contains Carboprost Trometamol BP equivalent to Carboprost 250 mcg.
In the following conditions related to second trimester abortion:
1. Failure of expulsion of the fetus during the course of treatment by another method;
2. Premature rupture of membranes in intrauterine methods with loss of drug and insufficient or absent uterine activity;
3. Requirement of a repeat intrauterine instillation of drug for expulsion of the fetus;
4. Inadvertent or spontaneous rupture of membranes in the presence of a previable fetus and absence of adequate activity for expulsion.
Treatment of postpartum hemorrhage due to the uterus failing to return to its normal size and who have not responded to conventional treatments.
An initial dose of 1 ml of Carbestop (containing the equivalent of 250 mcg of Carboprost) is to be administered intramuscularly. Subsequent doses of 250 mcg should be administered at 1½ to 3½ hour intervals depending on uterine response.
An optional test dose of 100 mcg (0.4 ml) may be administered initially. The dose may be increased to 500 micrograms (2 ml) if uterine contractility is judged to be inadequate after several doses of 250 mcg (1 ml).
The total dose administered of Carbestop should not exceed 12 mg and continuous administration of the drug for more than 2 days is not recommended.
2. For Refractory Postpartum Uterine Bleeding:
An initial dose of 250 mcg of Carbestop (1 ml) is to be given deep, intramuscularly (IM).
If needed the dose of 1 ml may be repeated between 15 to 90 minutes. The total dose of Carbestop should not exceed 2 mg (8 doses).
Endometritis, retained placental fragments, and excessive uterine bleeding occurred as the most common complications after abortion with Carboprost.
Use Carboprost cautiously in patients with a history of asthma, hypo- or hypertension, cardiovascular, renal or hepatic disease, anemia, jaundice, diabetes or epilepsy and compromised (scarred) uteri.
In few patients with chorioamnionitis, uterus may not respond to Carboprost.
Cervix should always be carefully examined immediately post-abortion.
2. Acute pelvic inflammatory disease