Somarant tablet: Each tablet contains Suvorexant INN 10 mg.
Recommended dose is 10 mg, no more than once per nighttaken before 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be increased, not to exceed 20 mg once daily.
Time to effect may be delayed if taken with or soon after a meal.
- not thinking clearly
- act strangely, confused, or upset
Need to evaluate for co-morbid diagnoses: Reevaluate if insomnia persists after 7 to 10 days of treatment.
There are no adequate and well-controlled studies in pregnant women. Somarant should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
An additive effect on psychomotor performance was observed when a single dose of 40 mg of Suvorexant was co-administered with a single dose of 0.7 g/kg alcohol. Suvorexant did not affect alcohol concentrations and alcohol did not affect Suvorexant concentrations.
Effects of Other Drugs on Suvorexant
Strong (e.g., ketoconazole or itraconazole) and moderate (e.g., diltiazem) CYP3A inhibitors significantly increased Suvorexant exposure. Strong CYP3A inducers (e.g., rifampin) substantially decreased Suvorexant exposure.
Effects of Suvorexant on Other Drugs
Suvorexant is unlikely to cause clinically significant inhibition of human CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or CYP2D6. Chronic administration of Suvorexant is unlikely to induce the metabolism of drugs metabolized by major CYP isoforms.
General symptomatic and supportive measures should be used, along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. As Suvorexant is highly protein-bound, hemodialysis is not expected to contribute to elimination of Suvorexant.