Lubistone 8 Capsule: each capsule contains Lubiprostone INN 8mcg
Lubistone 24 Capsule: each capsule contains Lubiprostone INN 24mcg
By increasing intestinal fluid secretion, Lubiprostone increases motility in the intestine, thereby facilitating the passage of stool and alleviating symptoms associated with chronic idiopathic constipation.
• Opioid-induced Constipation (OIC) in adults with chronic non-cancer pain.
• Irritable Bowel Syndrome with Constipation (IBS-C).
The recommended dose is 8 mcg twice daily orally with food and water.
Dosage in patients with hepatic impairment: Dosage adjustment is not required for patients with moderately impaired hepatic function. For patients with severely impaired hepatic function, the recommended starting dose is 8 mcg once daily. If tolerated then dose can be increased to 8mcg twice
Chronic Idiopathic Constipation and Opioid-induced Constipation:
The recommended dose is 24 mcg twice daily orally with food and water.
Dosage in patients with hepatic impairment: For patients with moderately impaired hepatic function, the recommended starting dose is 16 mcg twice daily. For patients with severely impaired hepatic function, the recommended starting dose is 8 mcg twice daily.
Diarrhea: Lubistone should not be prescribed to patients that have severe diarrhea.
Bowel Obstruction: In patients with symptoms suggestive of mechanical gastrointestinal obstruction, perform a thorough evaluation to confirm the absence of an obstruction prior to initiating therapy with Lubiprostone.
It is not known whether lubiprostone is excreted in human milk. Because lubiprostone increases fluid secretion in the intestine and intestinal motility, human milk-fed infants should be monitored for diarrhea. Caution should be exercised when Lubiprostone is administered to a nursing woman.
Lubistone 24 capsule: Each box contains 2 blister strips of 10 capsules.