Home > Products > Bisopro Plus
Share Print This Page

Bisopro Plus (Bisoprolol fumarate + Hydrochlorothiazide)
Therapeutic Group: Cardiovascular » Anti Hypertensive » Combined Antihypertensive Preparations

Bisopro 2.5 Plus: Each tablet contains Bisoprolol fumarate USP 2.5 mg and Hydrochlorothiazide BP 6.25 mg

Bisopro 5 Plus: Each tablet contains Bisoprolol fumarate USP 5 mg and Hydrochlorothiazide BP 6.25 mg

Bisoprolol is a beta1 selective (cardio selective) adrenoceptor blocking agent without significant membrane stabilizing activity or intrinsic sympathomimetic activity in its therapeutic dosage range.

Hydrochlorothiazide is a diuretic (benzothiadiazine) affecting the distal renal tubular mechanism increase excretion of sodium and chloride and resulting reduced blood volume or Cardiac output.

Individually Bisoprolol Fumarate and Hydrochlorothiazide used as antihypertensive agent and combination of these two drugs brings maximum response in treatment of hypertension. Hydrochlorothiazide significantly increases the antihypertensive effect of Bisoprolol Fumarate. The incidence of hypokalemia is less due to low dose of Hydrochlorothiazide.
Bisoprolol plus Hydrochlorothiazide is indicated in the treatment of Hypertension.
Dosage & Administration
Bisoprolol is an effective treatment of hypertension in once-daily doses of 2.5 mg to 40 mg, while hydrochlorothiazide is effective in doses of 12.5 mg to 50 mg. In clinical trials of bisoprolol/hydrochlorothiazide combination therapy using bisoprolol doses of 2.5 mg to 20 mg and hydrochlorothiazide doses of 6.25 mg to 25 mg.
Side Effects
Generally well tolerated. Most side effects have been mild and transient. Normally fatigue, dizziness, headache, bradycardia, arrhythmia, peripheral ischemia, chest pain, palpitations, rhythm disturbances, cold extremities, claudication, orthostatic hypotension, diarrhoea, constipation, nausea, dyspepsia, rhinitis, pharyngitis etc. may occur.
Dryness of mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances are potential syndrome of fluid and electrolyte imbalance.
Dilutional hyponatremia may occur in edematous patients in hot weather; appropriate therapy is water restriction rather than salt administration.
Hyperuricemia or acute gout may be precipitated in certain patients receiving thiazide diuretics. Bisoprolol fumarate, alone or in combination with hydrochlorothiazide, has been associated with increases in uric acid.
Bisoprolol fumarate and hydrochlorothiazide is contraindicated in patients in cardiogenic shock, overt cardiac failure, second or third degree AV block, marked sinus bradycardia, anuria, and hypersensitivity to either component of this product or to other sulfonamide-derived drugs.
Use in Pregnancy & Lactation
Use in special population:
Nursing Mothers: Thiazides are excreted in human breast milk. Small amounts of bisoprolol fumarate (< 2% of the dose) have been detected in the milk of lactating rats. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Use in Pregnancy: Pregnancy Category C.
Geriatric Use: No overall differences in effectiveness or safety were observed between these patients and younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out.
Drug Interaction
Bisoprolol should not be combined with other beta-blocking agents. Patients receiving catecholamine-depleting drugs should be closely monitored, because the added beta-adrenergic blocking action of Bisoprolol may produce excessive reduction of sympathetic activity. In patients receiving concurrent therapy with clonidine, if therapy is to be discontinued, it is suggested that Bisoprolol be discontinued for several days before the withdrawal of clonidine. Bisoprolol should be used with care when myocardial depressants or inhibitors of AV conduction, such as certain calcium antagonists or antiarrhythmic agents are used concurrently. Concomitant use with digitalis glycosides can increase the risk of bradycardia. Concurrent use of rifampin increases the metabolic clearance of Bisoprolol, resulting in a shortened elimination half-life of Bisoprolol. However, initial dose modification is generally not necessary.
There are limited data on overdose with bisoprolol fumarate and hydrochlorothiazide. The most frequently observed signs expected with overdosage of a beta-blocker are bradycardia and hypotension. Lethargy is also common, and with severe overdoses, delirium, coma, convulsions, and respiratory arrest have been reported to occur. Congestive heart failure, bronchospasm, and hypoglycemia may occur.
Store in a cool and dry place, protected from light.
Commercial Packaging
Bisopro 2.5 Plus : Each box contain 3 blister strips of 10 tablet.
Bisopro 5 Plus : Each box contain 3 blister strips of 10 tablet.
Products from the same therapeutic group
Anti Anginal
Trimetazidine Dihydrochloride tablet
Ivabradine Hydrochloride
Ranolazine 500 mg
Nitroglycerin 2.6 mg Capsule & Tablet
Trocer Spray
Nitroglycerin 0.4 mg Spray
Anti Coagulant
Enoxaparin Sodium BP
Rivaroxaban 10 & 15 mg Tablet
Warfarin tablet
Anti Fibrinolytic
Tranexamic acid BP
Anti Hypertensive
ARB Plain
Losartan Potassium Tablet
Valsartan tablet
Olmesartan Medoxomil 20 & 40 mg Tablet
ACE Inhibitor Plain
Ramipril tablet
ACE Inhibitor Combination
Benazepril plus Amlodipine
Indapamide and Perindopril Erbumine
Ramoril Plus
Ramipril & Hydrochlorothiazide Tablet
Carvedilol 6.25, 12.5 & 25 mg tablet
Metoprolol tartrate
Bisoprolol Fumarate 2.5 & 5 mg Tablet
Calcium Channel Blocker
Lercanidipine Hydrochloride film-coated tablet
Verapamil hydrochloride
Amlodipine tablet
Lacidipine 2 mg & 4 mg Tablet
Centrally Acting Antihypertensive
Combined Antihypertensive Preparations
Amlodipine plus Atenolol tablet
Osartil Plus
Losartan Potassium & Hydrochlorothiazide Tablet
Amlodipine & Valsartan tablet
Valsartil Plus
Valsartan & Hydrochlorothiazide tablet
Xyotil Plus
Olmesartan Medoxomil plus Hydrochlorothiazide
Bisopro Plus
Bisoprolol fumarate and Hydrochlorothiazide tablet
Hydrochlorothiazide tablet
Frusemide & Spironolactone Tablet
Indapamide 1.5 mg Tablet
Eplerenone 25 mg Tablet
Spironolactone 25 mg Tablet
Bumetanide 1 mg, 5 mg Tablet and 2 mg/4 ml IV/IM Injection
Anti Platelet
Eptifibatide INN
Clopidogrel tablet
Lopirel Plus
Clopidogrel & Aspirin Tablet
Prasugrel Hydrochloride INN tablet
Ticagrelor 90 mg Tablet
Lipid Lowering
Ezetimibe Tablet
Inositol nicotinate tablets
Fenofibrate Capsule
Ridel  ER
Niacin USP 500 mg Extended Release tablet
Rosuvastatin 5 & 10 mg Tablet
Atorvastatin 10 mg and Amlodipine 5 mg
Atorvastatin 10, 20 & 40 mg tablet
Sympathomimetics / Inotropes
Adrenaline 1 mg/ml IV, IM, SC injection
Dobutamine Hydrochloride USP
Dopamine Hydrochloride BP Injection

Other christian louboutin outlet collection comes in mermaid shoes cut. There are two samples of louboutin sneakers shown in the pictures. Both shoes are different indeed with stylish and creative details on certain areas such as skirt, waist and chest. To match the latest christian louboutin model, these mermaid cut wedding shoes a la princess of fairytale apply sweetheart strapless neckline cut. Thick ruffle details are applied on the first louboutin schuhe. The ruffle application is combined with pleated details on the louboutin shoes uk. Thus, in conclusion, the christian louboutin schuhe is extremely very marvelous for your modern fairytale bridal. Women always like louboutin. Sometimes, you will find louboutin damen schuhe online. But they are high quality louboutin schuhe deutschland. Best louboutin schuhe outlet for girls. The 1:1 christian louboutin are also perfect. Luxury louboutin schoenen for sale online.