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Windel ConviCap (Salbutamol)
Therapeutic Group: Respiratory » Anti Asthmatics » Bronchodilator
Presentation
Windel ConviCap

Windel ConviCap: Each capsule contains Salbutamol Sulphate BP equivalent to Salbutamol 200 µg inhalation powder.

Descriptions
Salbutamol is a beta-2-adrenergic agonist drug which produces bronchodilatation through stimulation of beta-2-adrenergic receptors of intracellular adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3\',5\'-adenosine monophosphate (cyclic AMP). Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Indications
For the relief of bronchospasm in patients with asthma or chronic obstructive pulmonary disease, and for acute prophylaxis against exercise-induced asthma or in other situations known to induce bronchospasm.
Dosage & Administration
Adults:
For the relief of acute asthma or before exercise 400 µg (2 ConviCaps). The recommended dose for maintenance treatment or prophylactic therapy is 400 µg (2 ConviCaps) three to four times a day. Maximum dose is 1600 µg/day.
Children:
In the treatment of episodic asthma or before exercise 200 µg (1 ConviCap). The recommended dose for maintenance treatment or prophylactic treatment is 200 µg (1 ConviCap) three to four times a day. Maximum dose is 800 µg/day.
Side Effects
Salbutamol may cause fine tremor of skeletal muscles (particularly the hands), palpitations and muscle cramps. Tachycardia, tenseness, headaches and peripheral vasodilatation have been reported after large doses.
Precautions
Salbutamol should be used with caution in patients with hyperthyroidism, cardiovascular disease, occlusive vascular disorders, hypertension and aneurysms. Hypokalaemia associated with high doses of Salbutamol may result in increased susceptibility to digitalis-induced cardiac arrhythmias. Tachyphylaxis with resistance may occur with prolonged use of high dosage. Care is necessary when treating patients with diabetes mellitus or closed-angle glaucoma, and in those receiving antihypertensive therapy.
Contraindications
Salbutamol is contraindicated in patients with a history of hypersensitivity to Salbutamol or any of its components.
Use in Pregnancy & Lactation
Pregnancy:
The drug should be used during pregnancy only if the potential benefit justifies the potential risk of the fetus.
Lactation:
It is not known whether this drug is excreted in human milk. Because of the potential of tumorigenecity shown for Salbutamol in some animal studies, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
Drug Interaction
Salbutamol should be administered with extreme caution to patients being treated with MAO inhibitors or tricyclic antidepressants since the action of Salbutamol on the cardiovascular system may be potentiated. Beta-adrenergic blocking drugs, especially the noncardioselective ones; may effectively antagonize the action of Salbutamol.
Overdose
The symptoms with overdose are angina, headache, nausea, vomiting, tremor etc. The preferred antidote for overdosage with Salbutamol is a cardio-selective beta-blocking agent but beta-blocking drugs should be used with caution in patients with a history of bronchospasm.
Storage
• Protect from light, store in cool & dry place
• Do not store above 30 °C.
• Keep out of the reach of children
• Protect from freezing
• Insert the ConviCap in the ConviHaler just prior to use to protect from deterioration by moisture.
Commercial Packaging
Windel ConviCap: Each box contains 5 alu-alu blister strips of 6 capsules.
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