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Metalone Plus Sterile Ophthalmic Suspension (Fluorometholone Acetate & Tetrahydrozoline)
Therapeutic Group: Ophthalmic » Steroidal Preparations
Presentation
Metalone Plus Sterile Ophthalmic Suspension

Metalone Plus Sterile Ophthalmic Suspension: Each ml contains Fluorometholone Acetate BP 1 mg and Tetrahydrozoline HCl BP 0.296 mg equivalent to Tetrahydrozoline 0.25 mg.

Descriptions
Metalone Plus is a combination preparation of Fluorometholone Acetate and Tetrahydrozoline. Fluorometholone Acetate is a moderately potent corticosteroid that shows anti inflammatory action by inhibiting release of inflammatory mediators. Tetrahydrozoline is an alpha agonist which constricts conjunctival blood vessels and reduces the redness of the eye caused by allergic reaction.
Indications
• Acute and chronic allergic non-infectious conjunctivitis and keratitis with severe swelling and intravascular injection

• Non-infectious inflammation of the anterior segment of the eye (including anterior uveitis, episcleritis and scleritis)

• Post-operative irritative conditions after strabismus; cataract & glaucoma surgery with supplementary antimicrobial therapy.
Dosage & Administration
Adults and children (above 2 years of age):
Instill 1-2 drops into conjunctivalsac 2-3 times daily. Dose may be increased to 1 drop hourly during first 24-48 hr.
Side Effects
Mild burning sensation, reversible increase in intra ocular pressure (IOP), reactive hyperemia/rebound effect, cataract & corneal defects, glaucoma, systemic effects (chronic use).
Precautions
• Prolonged use in pregnant women and infants should be avoided
• This medication should be used with caution in patients under treatment with MAO inhibitors
• Do not apply while wearing soft contact lenses. The lenses should be removed before application of the drops and not reinserted earlier than 15 minutes after use.
• Shake well before use.
Contraindications
This medication is contraindicated in following cases-
• Viral infection of cornea & conjunctiva caused by Herpes simplex etc
• Fungal infection of the cornea & conjunctiva
• Tuberculous infections
• Ulcerous processes of the cornea
• Hypersensitivity to any ingredients of this formulation.
Use in Pregnancy & Lactation
No adequate and well-controlled study of Fluorometholne Acetate & Tetrahydrozoline has been established during pregnancy & breast feeding. Therefore, this combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Drug Interaction
Tetrahydrozoline may interact with antidepressant drugs which inhibits Mono Amino Oxidase (MAO) Enzyme such as Isocarboxazid, phenelzine and its sulphate derivative, Toloxatone, Tranylcypromine and its sulphate derivative etc.
Overdose
Information not available.
Storage
• Keep out of the reach of children.
• Store in a cool, dry place, away from heat and direct light.
• Do not use more than 4 weeks after opening.
Commercial Packaging
Metalone Plus Sterile Ophthalmic Suspension: Each plastic dropper bottle contains 5 ml of eye drops.
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