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Resadol (Paracetamol & Tramadol Hydrochloride)
Therapeutic Group: Analgesic, Anti Inflammatory » NSAIDs/Non Opiod Analgesic
Presentation
Resadol

Resadol Tablet: Each film coated tablet contains Paracetamol BP 325 mg & Tramadol hydrochloride BP 37.5 mg.

Descriptions
Paracetamol is a non-opiate, non-salicylate analgesic. Tramadol is a centrally acting synthetic opioid analgesic. Although its mode of action is not completely understood, from animal tests, at least two complementary mechanisms appear applicable: binding of parent and M1 metabolite to m-opioid receptors and weak inhibition of reuptake of nor-epinephrine and serotonin.

Opioid activity is due to both low affinity binding of the parent compound and higher affinity binding of the O-demethylated metabolite M1 to m-opioid receptors.

As some other opioid analgesics, Tramadol has been shown to inhibit reuptake of nor-epinephrine and serotonin in vitro. These mechanisms may contribute independently to the overall analgesic profile of Tramadol.
Indications
Resadol tablet is indicated for the management of moderate to moderately severe pain in adults.

Resadol tablet is also indicated for the short-term (five days or less) management of acute pain.
Dosage & Administration
Resadol tablet can be administered without regard to food.
For the management of moderate to moderately severe pain, the recommended dose is 1 or 2 tablets every 4 to 6 hours as needed for pain relief up to a maximum of 8 tablets per day.
In case of short-term (five days or less) management of acute pain, the recommended dose is 2 tablets every 4 to 6 hours as needed for pain relief up to a maximum of 8 tablets per day.
Pediatric & geriatric use: The safety and effectiveness of this combination preparation has not been studied in the pediatric population. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function; of concomitant disease and multiple drug therapy.
Use in renal disease: This combination preparation has not been studied in patients with impaired renal function. In patients with creatinine clearances of less than 30 ml/min, it is recommended that the dosing interval of this combination preparation be increased but not to exceed 2 tablets every 12 hours.
Use in hepatic disease: This combination preparation has not been studied in patients with impaired hepatic function. The use of this combination preparation in patients with hepatic impairment is not recommended.
Side Effects
The following adverse reactions may happen to this therapy: asthenia, fatigue, hot flushes, dizziness, headache, tremor, abdominal pain, constipation, diarrhea, dyspepsia, dry mouth, nausea, vomiting, anorexia, anxiety, confusion, euphoria, insomnia, nervousness, somnolence pruritus, rash, increased sweating etc.
Precautions
This combination preparation may impair mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.
This combination preparation should not be taken with alcohol containing beverages.
The patient should be instructed not to take this combination preparation in combination with other Tramadol or Paracetamol-containing products, including over-the-counter preparations.
This combination preparation should be used with caution when taking medications such as tranquilizers, hypnotics or other opiate containing analgesics.
Contraindications
Tramadol & Paracetamol combination tablet should not be administered to patients who have previously demonstrated hypersensitivity to Tramadol, Paracetamol or any other component of this product or opioids. This is contraindicated in any situation where opioids are contraindicated.
Use in Pregnancy & Lactation
Pregnancy Category C
There are no adequate and well-controlled studies in pregnant women. This combination preparation should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
This combination preparation is not recommended for obstetrical preoperative medication or for post-delivery analgesia in nursing mothers because its safety in infants and newborns has not been studied.
Storage
Store in cool and dry place. Do not freeze.
Commercial Packaging
Resadol Tablet: Each commercial box contains 3 alu-pvdc blister strips of 10 tablets.
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