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Emenil Plus (Meclizine & Pyridoxine)
Therapeutic Group: Anti Emetic
Presentation
Emenil Plus

Emenil Plus : Each film-coated tablet contains Meclizine Hydrochloride USP 25 mg and Pyridoxine Hydrochloride BP 50 mg.

Descriptions
Meclizine is a piperazine-derivative antihistamine that is used as an antiemetic. It has antiemetic, anticholinergic and antihistaminic properties. It reduces the sensitivity of the labyrinthine apparatus. The action may be mediated through nerve pathways to the vomiting center (VC) from the chemoreceptor trigger zone (CTZ), peripheral nerve pathways, the VC, or other CNS centers. Pyridoxine is vitamin B-6. It has been added to enhance the anti-emetic effects & as a dietary suppliment.
Indications
Prevention and treatment of nausea, vomiting, dizziness, motion sickness, radiation sickness and vertigo associated with diseases of the vestibular system (e.g. Ménière's syndrome, labyrinthitis and other vestibular disturbances).
Dosage & Administration
Emenil Plus is administered orally.
Adult and Children 12 years of age & over: Nausea and vomiting: 25-50 mg daily or as directed by a physician.
Motion sickness: Take an initial dose of 25-50 mg, 1 hour prior to travel. May repeat the dose every 24 hours for the duration of the journey.
Radiation sickness: 50 mg administered 2-12 hours prior to radiation treatment.
Vertigo: 25-100 mg daily in divided doses.
Prevention of nausea and vomiting associated with emergency contraceptive pill (ECP) : 25-50 mg, 1 hour before first ECP dose; repeat if needed in 24 hours.
The safety and efficacy for use in children less than 12 years of age have not been established.
Side Effects
Drowsiness, dry mouth and, on rare occasions, blurred vision have been reported.
Precautions
Patients should be warned that Meclizine Hydrochloride may impair their ability to perform hazardous activities requiring mental alertness or physical coordination (e.g., operating machinery, driving a motor vehicle). Patients should avoid alcoholic beverages while taking this drug. Due to its potential anticholinergic action, this drug should be used with caution in patients with asthma, glaucoma or enlargement of the prostate gland.
Contraindications
Meclizine Hydrochloride and Pyridoxine Hydrochloride is contraindicated in patients who are hypersensitive to these ingredients.
Use in Pregnancy & Lactation
Pregnancy: Category B. Large scale human studies have not demonstrated adverse fetal effects. It has been suggested that based on available data, Meclizine presents the lowest risk of teratogenicity and is the drug of first choice in treating nausea and vomiting during pregnancy.
Lactation: Safety for use in the nursing mother has not been established.
Drug Interaction
The CNS depressant effects of Meclizine can be potentiated by concurrent use of Ethanol or other CNS depressant agents such as Benzodiazepines, Barbiturates, Tricyclic antidepressants, opiate agonists, skeletal muscle relaxants and antihistamines. Concurrent use of other anticholinergics can potentiate the anticholinergic effects of Meclizine. Meclizine can increase the absorption of digoxin by decreasing gastrointestinal motility.
Overdose
Symptoms: Extreme excitability, seizures, drowsiness and hallucinations.
Treatment: Appropriate supportive and symptomatic treatment. Consider dialysis.
Commercial Packaging
Emenil Plus : Each box contains 10 blister strips of 10 tablets.
Products from the same therapeutic group
Anti Emetic
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Meclizine Hydrochloride film-coated tablet
Emenil Plus
Meclizine Hydrochloride & Pyridoxine Hydrochloride film-coated tablet
Emestop
Aprepitant Capsule
Omidon
Domperidone tablet/dispersible tablet/suspension/paediatric drops
Onaseron
Ondansetron Hydrochloride Dihydrate BP
Paloxiron
Palonosetron Hydrochloride injection
 
 

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