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Kolchin (Colchicine)
Therapeutic Group: Anti Gout » Anti-inflammatory
Presentation

Kolchin 0.5 mg tablet: Each tablet contains Colchicine USP 0.5 mg.

Kolchin 0.6 mg tablet: Each tablet contains Colchicine USP 0.6 mg.

Descriptions
Kolchin is FDA-approved to help prevent gout and to treat sudden severe attacks of gout. In gout, crystals of uric acid are deposited in certain joints. White blood cells migrate to the areas of the body where uric acid has been deposited. They attempt to engulf the crystals, and as a result, lactic acid and pro-inflammatory enzymes are released. These substances give rise to the characteristic pain and swelling of gout.

Kolchin inhibits the migration of the white blood cells into the inflamged area, causing a reduction in pain and inflammation.
Indications
Prophylaxis and treatment of gout flares in adults.

Familial Mediterranean fever (FMF) in adults and children 4 years or older.
Dosage & Administration
Acute gouty arthritis: Articular pain and swelling typically reduced within 12 hours and are usually gone in 24 to 48 hours, an interval of three days between colchicine courses is advised in order to minimize the possibility of cumulative toxicity. The total amount of colchicine needed to control pain and inflammation during an attack usually ranges from 4 to 8 mg. First dose- 1 to 1.2 mg (two 0.5 mg or two 0.6 mg tablets) at a time, then one (0.5 mg or 0.6 mg) tablet every 2 hours until pain and inflammation aborted.
For prophylaxis during intercritical periods: Severe cases may require two or three 0.5 mg or 0.6 mg tablets daily. For cases involving more than one attack per year, the usual dose is 0.5 or 0.6 mg daily. In patients who have less than one attack per year, the usual dose is 0.5 or 0.6 mg per day, three or four days a week. To reduce the frequency of their severity, colchicine may be administered continuously.
For prophylaxis against attacks of gout in patients undergoing surgery: In patients with gout, an attack may be precipitated by even a minor surgical procedure. One 0.5 mg tablet or one 0.6 mg tablet three times daily should be administered for three days before and three days after surgery.
Side Effects
Nausea, vomiting, and abdominal pain. Excessive doses may cause profuse diarrhea.
Precautions
Keep Kolchin out of the reach of children.
Contraindications
Blood disorders.
Use in Pregnancy & Lactation
There are no adequate studies of Kolchin in pregnant women.
Nursing mothers: Kolchin is excreted into human milk and may cause adverse effects in the infant.
Drug Interaction
Co-administration with clarithromycin or Cyclosporine have been demonstrated to alter the concentration of Kolchin.
Overdose
If overdose is suspected, contact a poison control center or emergency room immediately.
Commercial Packaging
Commercial pack:
Kolchin 0.5 mg tablet: Each box contains 3 blister strips of 10 tablets
Kolchin 0.6 mg tablet: Each box contains 3 blister strips of 10 tablets.
Products from the same therapeutic group
Anti Gout
Anti-inflammatory
Kolchin
Colchicine USP 0.5 mg and 0.6 mg tablet
Uricosuric Agent
Pyrazone
Pyrazone
Xanthine Oxidase Inhibitor
Alurol
Allopurinol tablet
Febustat
Febuxostat 40 and 80 mg tablet
 
 

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