Home > Products > Prasurel
Share Print This Page

Prasurel (Prasugrel)
Therapeutic Group: Cardiovascular » Anti Platelet
Presentation

Prasurel 5: Each tablet contains Prasugrel Hydrochloride INN which is eq. to prasugrel 5 mg.

Prasurel 10: Each tablet contains Prasugrel Hydrochloride INN which is eq. to prasugrel 10 mg.

Descriptions
Prasurel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.
Indications
Prasurel is indicated to reduce the rate of thrombotic cardiovascular (CV) events (including stent thrombosis) in patients with acute coronary syndrome (ACS) who are to be managed with percutaneous coronary intervention (PCI) as follows:

- Patients with unstable angina (UA) or non-ST-elevation myocardial infarction (NSTEMI).

- Patients with ST-elevation myocardial infarction (STEMI) when managed with primary or delayed PCI.
Dosage & Administration
Treatment should be initiated with a single 60 mg oral loading dose.
Continue at 10 mg once daily with or without food. Consider 5 mg once daily for patients < 60 kg. Patients should also take aspirin (75 mg to 325 mg) daily.
Pediatric Use: Safety and effectiveness in pediatric patients have not been established
Geriatric Use: Patients > 75 years of age who received Prasugrel had an increased risk of fatal bleeding events (1.0%) compared to patients who received clopidogrel (0.1%).
Renal Impairment: No dosage adjustment is necessary for patients with renal impairment. There is limited experience in patients with end-stage renal disease
Hepatic Impairment: No dosage adjustment is necessary in patients with mild to moderate hepatic impairment.
Side Effects
- Bleeding
- Thrombotic thrombocytopenic purpura
- Other side effects ( Headache, back pain, dyspnea, nausea, hypertension, bradycardia, rash etc)
Precautions
CABG-related bleeding: Risk increases in patients receiving Prasurel who undergo CABG.

Discontinuation of Prasugrel: Premature discontinuation increases risk of stent thrombosis, MI, and death
Contraindications
Active pathological bleeding such as peptic ulcer or intracranial hamorrhage. Patient with a history of prior transient ischemic attack or stroke
Use in Pregnancy & Lactation
Pregnancy:
Pregnancy Category B - There are no adequate and well-controlled studies of Prasugrel use in pregnant women. Reproductive and developmental toxicology studies in rats and rabbits at doses of up to 30 times the recommended therapeutic exposures in humans revealed no evidence of fetal harm; however, animal studies are not always predictive of a human response.
Nursing Mothers:
It is not known whether Prasugrel is excreted in human milk. Because many drugs are excreted in human milk, prasugrel should be used during nursing only if the potential benefit to the mother justifies the potential risk to the nursing infant.
Drug Interaction
Coadministration of Prasugrel and warfarin increases the risk of bleeding. Coadministration of Prasugrel and NSAIDs (used chronically) may increase the risk of bleeding.

Prasurel can be administered with drugs that are inducers or inhibitors of cytochrome P450 enzymes. Prasurel can be administered with aspirin (75 mg to 325 mg per day), heparin, GPIIb/IIIa inhibitors, statins, digoxin, and drugs that elevate gastric pH, including proton pump inhibitors and H2 blockers.
Overdose
In rats, lethality was observed after administration of 2000 mg/kg. Platelet transfusion may restore clotting ability. The prasugrel active metabolite is not likely to be removed by dialysis.
Commercial Packaging
Prasurel 5: Each box contains 3 blister strips of 10 tablets.
Prasurel 10: Each box contains 2 blister strips of 10 tablets.
Products from the same therapeutic group
Cardiovascular
Anti Anginal
Angifix
Isosorbide-5-Mononitrate
Feelnor
Trimetazidine Dihydrochloride tablet
Ivaprex
Ivabradine Hydrochloride
Ralozine
Ranolazine 500 mg
Trocer
Nitroglycerin 2.6 mg Capsule & Tablet
Trocer Spray
Nitroglycerin 0.4 mg Spray
Anti Coagulant
Parinox
Enoxaparin Sodium BP
Roxarel
Rivaroxaban 10 & 15 mg Tablet
Warin
Warfarin tablet
Anti Fibrinolytic
Intrax
Tranexamic acid BP
Anti Hypertensive
ARB Plain
Osartil
Losartan Potassium Tablet
Valsartil
Valsartan tablet
Xyotil
Olmesartan Medoxomil 20 & 40 mg Tablet
ACE Inhibitor Plain
Ramoril
Ramipril tablet
ACE Inhibitor Combination
Benadip
Benazepril plus Amlodipine
Indapril
Indapamide and Perindopril Erbumine
Ramoril Plus
Ramipril & Hydrochlorothiazide Tablet
β-Blocker
Carvista
Carvedilol 6.25, 12.5 & 25 mg tablet
Presonil
Metoprolol tartrate
Bisopro
Bisoprolol Fumarate 2.5 & 5 mg Tablet
Calcium Channel Blocker
Larcadip
Lercanidipine Hydrochloride film-coated tablet
Veracal
Verapamil hydrochloride
Amlotab
Amlodipine tablet
Lacidip
Lacidipine 2 mg & 4 mg Tablet
Centrally Acting Antihypertensive
Sardopa
Methyldopa
Combined Antihypertensive Preparations
Fixocard
Amlodipine plus Atenolol tablet
Osartil Plus
Losartan Potassium & Hydrochlorothiazide Tablet
Amlosartan
Amlodipine & Valsartan tablet
Valsartil Plus
Valsartan & Hydrochlorothiazide tablet
Xyotil Plus
Olmesartan Medoxomil plus Hydrochlorothiazide
Bisopro Plus
Bisoprolol fumarate and Hydrochlorothiazide tablet
Diuretic
Acuren
Hydrochlorothiazide tablet
Edeloss
Frusemide & Spironolactone Tablet
Idatix
Indapamide 1.5 mg Tablet
Epleron
Eplerenone 25 mg Tablet
Inospiron
Spironolactone 25 mg Tablet
Bumecard
Bumetanide 1 mg, 5 mg Tablet and 2 mg/4 ml IV/IM Injection
Anti Platelet
Integril
Eptifibatide INN
Lopirel
Clopidogrel tablet
Lopirel Plus
Clopidogrel & Aspirin Tablet
Prasurel
Prasugrel Hydrochloride INN tablet
Ticarel
Ticagrelor 90 mg Tablet
Lipid Lowering
Ezetim
Ezetimibe Tablet
Nicosit
Inositol nicotinate tablets
Nofiate
Fenofibrate Capsule
Ridel  ER
Niacin USP 500 mg Extended Release tablet
Rocovas
Rosuvastatin 5 & 10 mg Tablet
Syncard
Atorvastatin 10 mg and Amlodipine 5 mg
Tiginor
Atorvastatin 10, 20 & 40 mg tablet
Sympathomimetics / Inotropes
Adrinor
Adrenaline 1 mg/ml IV, IM, SC injection
Dobutin
Dobutamine Hydrochloride USP
Myomine
Dopamine Hydrochloride BP Injection
 
 

Other christian louboutin outlet collection comes in mermaid shoes cut. There are two samples of louboutin sneakers shown in the pictures. Both shoes are different indeed with stylish and creative details on certain areas such as skirt, waist and chest. To match the latest christian louboutin model, these mermaid cut wedding shoes a la princess of fairytale apply sweetheart strapless neckline cut. Thick ruffle details are applied on the first louboutin schuhe. The ruffle application is combined with pleated details on the louboutin shoes uk. Thus, in conclusion, the christian louboutin schuhe is extremely very marvelous for your modern fairytale bridal. Women always like louboutin. Sometimes, you will find louboutin damen schuhe online. But they are high quality louboutin schuhe deutschland. Best louboutin schuhe outlet for girls. The 1:1 christian louboutin are also perfect. Luxury louboutin schoenen for sale online.