Prasurel 5: Each tablet contains Prasugrel Hydrochloride INN which is eq. to prasugrel 5 mg.
Prasurel 10: Each tablet contains Prasugrel Hydrochloride INN which is eq. to prasugrel 10 mg.
- Patients with unstable angina (UA) or non-ST-elevation myocardial infarction (NSTEMI).
- Patients with ST-elevation myocardial infarction (STEMI) when managed with primary or delayed PCI.
Continue at 10 mg once daily with or without food. Consider 5 mg once daily for patients < 60 kg. Patients should also take aspirin (75 mg to 325 mg) daily.
Pediatric Use: Safety and effectiveness in pediatric patients have not been established
Geriatric Use: Patients > 75 years of age who received Prasugrel had an increased risk of fatal bleeding events (1.0%) compared to patients who received clopidogrel (0.1%).
Renal Impairment: No dosage adjustment is necessary for patients with renal impairment. There is limited experience in patients with end-stage renal disease
Hepatic Impairment: No dosage adjustment is necessary in patients with mild to moderate hepatic impairment.
- Thrombotic thrombocytopenic purpura
- Other side effects ( Headache, back pain, dyspnea, nausea, hypertension, bradycardia, rash etc)
Discontinuation of Prasugrel: Premature discontinuation increases risk of stent thrombosis, MI, and death
Pregnancy Category B - There are no adequate and well-controlled studies of Prasugrel use in pregnant women. Reproductive and developmental toxicology studies in rats and rabbits at doses of up to 30 times the recommended therapeutic exposures in humans revealed no evidence of fetal harm; however, animal studies are not always predictive of a human response.
It is not known whether Prasugrel is excreted in human milk. Because many drugs are excreted in human milk, prasugrel should be used during nursing only if the potential benefit to the mother justifies the potential risk to the nursing infant.
Prasurel can be administered with drugs that are inducers or inhibitors of cytochrome P450 enzymes. Prasurel can be administered with aspirin (75 mg to 325 mg per day), heparin, GPIIb/IIIa inhibitors, statins, digoxin, and drugs that elevate gastric pH, including proton pump inhibitors and H2 blockers.
Prasurel 10: Each box contains 2 blister strips of 10 tablets.