Home > Products > Sitagil
Share Print This Page

Sitagil (Sitagliptin)
Therapeutic Group: Anti Diabetic » Oral hypoglycaemic
Presentation

Sitagil 25: Each tablet contains Sitagliptin Phosphate INN eq.to Sitagliptin 25 mg.

Sitagil 50: Each tablet contains Sitagliptin Phosphate INN eq.to Sitagliptin 50 mg.

Sitagil 100: Each tablet contains Sitagliptin Phosphate INN eq.to Sitagliptin 100 mg.

Descriptions
Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor, which exerts its action by slowing the inactivation of incretin hormones. Incretin hormones, including glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day and levels are increased in response to a meal. These hormones are rapidly inactivated by the enzyme, DPP-4. The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells by intracellular signaling pathways involving cyclic AMP. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production.
Indications
Sitagil is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Sitagil is indicated as monotherapy and also indicated for use in combination with metformin, sulfonylurea or thiazolidinediones when diet and exercise plus the single agent does not result in adequate glycemic control.
Dosage & Administration
- The recommended dose of Sitagliptin is 100 mg once daily. Sitagliptin can be taken with or without food.
- For patients with mild renal insufficiency ( creatinine clearance [CrCl]>50ml/min), no dosage adjustment is required.
- For patients with moderate renal insufficiency ( CrCl.>30 to <50 ml/min women), the dose of Sitagliptin is 50 mg once daily.
- For patients with severe renal insufficiency (CrCl<30 ml/min) or with end-stage renal disease (ESRD) requiring hemodialysis or peritoneal dialysis, the dose of Sitagliptin is 25 mg once daily.

Pediatric Use:
Safety and effectiveness of Sitagliptin in pediatric patients under 18 years of age have not been established.

Geriatric Use:
No overall differences in safety or effectiveness were observed between subjects over 65 years. The drug is excreted by the kidney. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection in the elderly.
Side Effects
Adverse reactions like upper respiratory tract infection, nasopharyngitis, and headache can occur. Hypoglycemia occurs in patients treated with the combination of Sitagliptin and sulfonylurea, with or without Metformin.
Precautions
- Dosage adjustment is recommended in patients with moderate or severe renal insufficiency and in patients with ESRD.

- When used with a sulfonylurea a lower dose of sulfonylurea may be required to reduce the risk of hypoglycemia.
Contraindications
Hypersensitivity reactions such as anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome can occur.
Use in Pregnancy & Lactation
Pregnanacy: Safety in pregnant women has not been established. Sitagliptin should be used during pregnancy only if the potential benefit justifies the potential risk of the fetus.

Nursing mothers: It is not known whether Sitagliptin is secreted in human milk, it should not be administered to a breast feeding woman.
Drug Interaction
There was a slight increase in the area under the curve and mean peak drug concentration of Digoxin with the co-administration of 100 mg Sitagliptin for 10 days.
Overdose
In the event of an overdose, it is reasonable to employ the usual supportivemeasures as dictated by the patient’s clinical status. Sitagliptin is modestly dialyzable. Prolonged hemodialysis may be considered if clinically appropriate.
Commercial Packaging
Sitagil 25: Each box contains 3 blister strips of 10 tablets

Sitagil 50: Each box contains 2 blister strips of 10 tablets

Sitagil 100: Each box contains 1 blister strip of 10 tablets
Products from the same therapeutic group
Anti Diabetic
Insulin and Its Preparations
Maxsulin
Human Insulin (rDNA)
Vibrenta
Insulin Glargine (rDNA) Injection
Oral hypoglycaemic
Compimet
Pioglitazone Hydrochloride & Metformin Hydrochloride
Consucon
Gliclazide
Linatab
Linagliptin INN
Linatab M
Linagliptin + Metformin HCl Tablet
Losucon
Glimepiride Tablet
Nobesit
Metformin Hydrochloride
Nomopil
Repaglinide 0.5,1,2 mg Raditab
Piodar
Pioglitazone tablet
Sitagil
Sitagliptin Phosphate INN
Sitagil M ER
Sitagliptin Phosphate Monohydrate INN 64.25 mg eq. to Sitagliptin 50mg & Metformin HCl BP 500 mg
 
 

Other christian louboutin outlet collection comes in mermaid shoes cut. There are two samples of louboutin schoenen shown in the pictures. Both shoes are different indeed with stylish and creative details on certain areas such as skirt, waist and chest. To match the latest replica handbags model, these mermaid cut wedding shoes a la princess of fairytale apply sweetheart strapless neckline cut. Thick ruffle details are applied on the first replica designer handbags. The ruffle application is combined with pleated details on the louboutin shoes uk. Thus, in conclusion, the christian louboutin schuhe is extremely very marvelous for your modern fairytale bridal. Women always like replica handbags uk. Sometimes, you will find cheap replica handbags online. But they are high quality replica handbags. Best replica handbags outlet for girls. The 1:1 replica bags are also perfect. Luxury designer replica handbags for sale online.