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Brimodin Eye Drops (Brimonidine Tartrate)
Therapeutic Group: Ophthalmic » Anti Glaucoma Preparations
Presentation
Brimodin Eye Drops

Each ml contains Brimonidine Tartrate INN 2 mg.

Descriptions
Brimodin contains the active ingredient brimonidine. It is a relatively selective alpha-2 adrenergic receptor agonist and approximately 1000 times more selective for the alpha-2 adrenoceptor than the alpha-1 adrenoceptor.

Topical administration of brimonidine decreases intraocular pressure (IOP) in humans. When used as directed, brimonidine ophthalmic solution reduces elevated IOP with minimal effect on cardiovascular parameters.

Brimonidine has a rapid onset of action, with the peak ocular hypotensive effect occurring at approximately 2 hours post-dosing. The duration of effect is 12 hours or greater.

Fluorophotometric studies in animals and humans suggest that brimonidine has a dual mechanism of action. Brimonidine lowers IOP by reducing aqueous humor production and increasing uveoscleral outflow.
Indications
It is effective for lowering intraocular pressure in patients with chronic open-angle glaucoma or ocular hypertension.
Dosage & Administration
The recommended dose is 1 drop of ophthalmic solution in the affected eye(s) twice daily (doses taken approximately 12 hours apart).
If more than one topical ophthalmic medicine is to be used, other eye drops should not be used within 5 to 10 minutes of using this eye drops.
Pediatric Use: Safety and effectiveness in pediatric patients have not been established.
Side Effects
Headache; itching of eye; redness of eye or inner lining of eyelid; swelling of eyelid; tearing of eye.
Precautions
General
Brimonidine ophthalmic solution 0.2% should be used with caution in patients with known hypersensitivity to other alpha-adrenoceptor agonists.

Although brimonidine had minimal effect on blood pressure and heart rate of patients in clinical studies, caution should be exercised in treating patients with severe cardiovascular disease.

Brimonidine has not been studied in patients with hepatic or renal impairment; caution should be exercised in treating such patients.

Brimonidine should be used with caution in patients with depression, cerebral or coronary insufficiency.
Contraindications
This eye drops are contraindicated in patients with hypersensitivity to brimonidine tartrate or any component of this medication.This product is also contraindicated in patients receiving monoaminase oxidase inhibitor therapy.
Use in Pregnancy & Lactation
Pregnancy:
Brimonidine has not been studied in pregnant women. Studies in animals have shown that brimonidine crosses the placenta, but very high doses have not been shown to cause harmful effects in the fetus.
Lactation:
It is not known whether brimonidine passes into human breast milk. However, it has been shown to pass into the milk of nursing animals.
Drug Interaction
Although specific drug interaction studies have not been conducted with brimonidine, the possibility of an additive or potentiating effect with CNS depressants (alcohol, barbiturates, opiates, sedatives, or anesthetics) should be considered.
Overdose
No data is available on overdosage of brimonidine ophthalmic solution in humans.
Storage
Store in a cool, dry place & protected from light.
Keep out of reach of children.
Do not use more than 4 weeks after opening.
Commercial Packaging
Each plastic dropper bottle contains 5 ml of sterile eye drops.
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