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Oroconazol (Miconazole)
Therapeutic Group: Skin » Anti Fungal
Presentation
Oroconazol

Oroconazol Oral Gel: Each gram gel contains Miconazole BP 20 mg.

Descriptions
Miconazole is a synthetic imidazole antifungal agent with a broad spectrum of activity against the common dermatophytes and yeasts as well as an antibacterial activity against certain gram positive bacilli and cocci. It acts by inhibiting ergosterol biosynthesis in fungi and change in the lipid components in the membrane, resulting in fungal cell necrosis.
Indications
Oral treatment and prevention of fungal infections of the oropharynx and gastrointestinal tract and of superinfections due to Gram-positive bacteria, including oral candidiasis and denture stomatitis.
Dosage & Administration
For oral administration

Dosage is based on 15 mg/kg/day

Adults: One or two spoonfuls (5-10 ml) of gel four times daily.
Children aged 6 years and over: One spoonful (5 ml) of gel four times daily.
Children aged 2-6 years: One spoonful (5 ml) of gel twice daily.
Infants under 2 years: Half spoonful (2.5 ml) of gel twice daily.

For localised lesions of the mouth, a small amount of gel may be applied directly to the affected area with a clean finger. For topical treatment of the oropharynx, the gel should be kept in the mouth for as long as possible.Treatment should be continued for up to 2 days after the symptoms have cleared. For oral candidiosis, dental prostheses should be removed at night and brushed with the gel.
Side Effects
Occasionally nausea and vomiting have been reported, and with long-term treatment diarrhea. In rare instances allergic reactions have been reported.
Precautions
If the concomitant use of Miconazole and Anticoagulant is considered, the anti-coagulant effect should be monitored and titrated. In infants and young children, caution must be taken to ensure that the gel does not obstruct the throat. Hence, the gel should not be applied to the back of the throat and the full dose should be divided into smaller portions.
Contraindications
The drug is contraindicated in individuals with a history of sensitivity reactions to Miconazole or any of the components of the preparation.
Use in Pregnancy & Lactation
During pregnancy, this medication should be used only when clearly needed.

It is not known whether this drug passes into breast milk.
Drug Interaction
Miconazole can inhibit the metabolism of drugs metabolized by the Cytochrome P450-3A and -2C9 families. Miconazole oral gel should not be used during treatment with terfenabine, astemizole, mizolastine, triazolam, oral midazolam, quinidine, simvastatin and lovastatin.
Overdose
In general, Miconazole is not highly toxic. In the event of accidental overdosage, vomiting and diarrhea may occur.
Commercial Packaging
Oroconazol Oral Gel: Tube containing 15 gram of Miconazole oral gel.
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