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Dilate Plus (Tropicamide & Phenylephrine Hydrochloride )
Therapeutic Group: Ophthalmic » Mydriatics & Cycloplegics
Presentation
Dilate Plus

Each ml contains Tropicamide BP 8 mg and Phenylephrine Hydrochloride BP 50 mg.

Descriptions
Dilate Plus sterile eye drops is a combination of Tropicamide and Phenylephrine Hydrochloride. Tropicamide is an anticholinergic agent which paralyses the sphincter muscle of the iris resulting in pupillary dilatation. The ciliary muscle is also paralyzed leading to loss of accommodation.

Phenylephrine Hydrochloride is an alpha receptor sympathetic agonist used in local ocular disorder because of its vasoconstrictor and mydriatic action without cycloplegia.
Indications
Dilate Plus can be used both for diagnostic and therapeutic purpose:

• Therapeutic purpose: Inflammatory conditions of the uveal tract

• Diagnostic purpose: Retinal photography, Refractive errors, Funduscopy, Slit lamp examination

• Pre-operative use : In order to undergo surgical procedure that requires the visualization of structures behind the iris, such as cataract extraction, vitrectomy and retinal detachment surgery, the pupil must be adequately dilated before surgery.
Dosage & Administration
Therapeutic purpose:
Uveitis: 1-2 drops bid-qid or as required.

Diagnostic purpose/Pre-operative purpose: Instill 1-2 drops in the eye(s) 15-20 minutes before examination. If examination is not conducted within 20–30 minutes, an additional drop may be placed in the eye(s) to prolong the effect.
Side Effects
Elevated IOP (occasionally), stinging, blurred vision, tachycardia, photophobia, headache, parasympathetic stimulation and allergic reactions. Systemic effects include arrhythmias, hypertension and coronary artery spasm.
Precautions

  • Caution should be taken when administered with, or upto 21days after administration of monoamine oxidase (MAO) inhibitors as exaggerated adrenergic effects may result.

  • The possibility of psychotic reactions and behavioral disturbances should be considered in patients who are hypersensitive to anticholinergic drugs.

  • Use with extreme caution in infants.

Contraindications
This medication is contraindicated in these following cases

  • Patients with hypersensitivity to any of the components and narrow angles or narrow angle glaucoma.

  • Low birth weight infants and some elderly adults with severe arteriosclerotic cardiovascular or cerebrovascular disease.

  • During intraocular operative procedures when the corneal epithelial barrier has been disturbed.


Use in Pregnancy & Lactation
The safety of this medication during pregnancy or lactation has not been established.
Drug Interaction
Tropicamide may interfere with the antihypertensive action of carbachol, pilocarpine or ophthalmic cholinesterase inhibitors.
Overdose
Excessive use in children and in certain susceptible individuals may produce systemic toxic symptoms.
Storage
Keep out of the reach of children.
Store in a cool, dry place, away from heat and direct light.
Do not use more than 4 weeks after opening.
Commercial Packaging
Plastic dropper bottle containing 5ml sterile Eye Drops.
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