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Apalene (Adapalene)
Therapeutic Group: Skin » Retinoid
Presentation
Apalene

Apalene 0.1% Cream: Each gram cream contains Adapalene INN 1 mg.

Descriptions
Adapalene is a retinoid-like compound. Biochemical and pharmacological profile studies have demonstrated that adapalene is a potent modulator of cellular differentiation, keratinisation and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Adapalene binds to specific retinoic acid nuclear receptors that normalises the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Indications
Apalene cream is indicated for the topical treatment of acne vulgaris of the face, chest or back.
Dosage & Administration
A thin film topical cream should be applied to the affected areas once a day before bedtime, after washing. The affected areas should be dry before application.
Side Effects
Local reactions include burning, erythema, stinging, pruritus, dry or peeling skin. Increased sensitivity to UVB light or sunlight occurs.
Precautions
Apalene cream should not come into contact with the eyes, lips mouth and mucous membranes, angles of the nose or broken skin (cuts and abrasions). If product enters the eye, wash with warm water. Because of a potential for increased irritation Apalene cream should not be used by patients with eczema or seborrhoeic dermatitis. If a reaction suggesting severe irritation occurs, discontinue use of the medication. If the irritation is not severe, use the medication less frequently, discontinue use temporarily until symptoms subside, or discontinue use altogether.
Contraindications
Pregnancy
Individuals who have hypersensitivity to any of its components
Use in Pregnancy & Lactation
Pregnancy: Category C. There are no well-controlled studies in pregnant women.

Nursing Mothers: It is not known whether Adapalene is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Apalene 0.1% cream is administered to a lactating mother.
Drug Interaction
There are no known interactions with other medications, which might be used topically and concurrently with adapalene topical cream. Other retinoids or drugs with a similar mode of action should not be used concurrently with adapalene. Absorption of adapalene through human skin is low and therefore no interaction with systemic medication.
Overdose
If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling or discomfort may occur.
Commercial Packaging
Apalene 0.1% Cream: Each tube contains 10 gm cream.

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