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Topicazole (Miconazole Nitrate)
Therapeutic Group: Skin » Anti Fungal
Presentation
Topicazole

Topicazole Cream: Each gram cream contains Miconazole Nitrate BP 20 mg.

Descriptions
Miconazole Nitrate is a broad spectrum antifungal agent. The range of action of Miconazole covers all dermatomycoses caused by the following pathogens:

Phycomycetes, Ascomycetes and Adelomycetes (e.g. Saprolegnia, Candida, Cryptococcus, Aspergillus, Dermatophytes, Phialophora, Sporotrichum), and Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum. Trichophyton interdigitale and Microsporum canis.

Miconazole Nitrate also possesses some anti-bacterial activity against Gram-positive organisms.

Indications
Dermatomycoses, e.g.:

-Tinea pedis (Athlete's foot)

-Tinea corporis (Tinea circinata)

-Tinea manuum

-Tinea cruris due to:

Trichophyton mentagrophytes

Trichophyton rubrum

Microsporum audouinii

Epidermophyton floccosum

-Candidial infections

-Tinea versicolor.

-Infections of the skin (e.g. intertrigo)

-Perianal infections

-Stomatitis angularis (cheilitis)

-Balanoposthitis

-Otitis externa

In addition miconazole cream has a very rapid alleviating effect on the pruritis which frequently accompanies infection.

Dosage & Administration
Sufficient Miconazole Cream should be applied to cover affected areas twice daily (morning and evening) in patients with tinea pedis, tinea cruris, tinea corporis and cutaneous candidiasis and once daily in patients with tinea versicolor. If Miconazole Cream is used in intertriginous areas it should be applied sparingly and smoothed in well to avoid maceration effects.
Early relief of symptoms (2 to 3 days) is experienced by the majority of patients and clinical improvement may be seen fairly soon after treatment is begun.All lesions usually disappear after 2 to 5 weeks.Prolong treatment for 10 days to prevent relapse. However, Candida infections, tinea cruris and corporis should be treated for two weeks and tinea pedis for one month in order to reduce the possibility of recurrence.
Side Effects
Irritation, burning, maceration and allergic contact dermatitis may occur.
Precautions
For external use only. Avoid introduction into the eyes.
Contraindications
The drug is contraindicated in individuals with a history of sensitivity reactions to Miconazole or any of the components of the preparation.
Use in Pregnancy & Lactation
During pregnancy, this medication should be used only when clearly needed.
It is not known whether this drug passes into breast milk.
Commercial Packaging
Topicazole Cream: Each tube contains 10 gm cream.
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