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Simplovir Cream (Aciclovir)
Therapeutic Group: Anti Viral » Herpes Simplex & Varicella Zoster Medication
Presentation
Simplovir Cream

Simplovir cream: Each gram cream contains Aciclovir BP 50 mg.

Descriptions
Aciclovir is a synthetic purine derivative. It exerts its antiviral effect on Herpes simplex viruses (HSV) and Varicella zoster (VZV) virus by interfering with DNA synthesis and inhibiting viral replication. In cells infected with virus, the antiviral activity of Aciclovir appears to depend principally on the intracellular conversion of the drug to Aciclovir triphosphate which is the pharmacologically active form of the drug.
Indications
Aciclovir cream is indicated for the treatment of initial and recurrent labial and genital Herpes simplex infections.
Dosage & Administration
Aciclovir should be applied to lesions every 4 hours for 5 days. If, after 5 days, healing is not complete then treatment may be continued for a further 5 days. The affected area should be kept clean and dry. In case of genital Herpes simplex infection patients should be wear loose-fitting cloths to avoid irritation to the lesions or as directed by the physician.
Side Effects
Edema, pain, pruritus, rash may occur
Precautions
Aciclovir cream is not recommended for application to buccal or vaginal mucous membrane. Care should be taken to avoid accidental introduction into the eye.
Contraindications
The drug is contraindicated in those patients with a history of hypersensitivity to Aciclovir or any of the components of the preparation.
Use in Pregnancy & Lactation
Pregnancy: Pregnancy category B.
Lactation: It is not known whether this drug is excreted in human milk.
Commercial Packaging
Simplovir Cream: Each tube contains 5 gm cream.
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