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Pyrazone (Sulphinpyrazone)
Therapeutic Group: Anti Gout » Uricosuric Agent
Presentation
Pyrazone

Pyrazone : Each tablet contains Sulfinpyrazone BP 200 mg.

Descriptions
Pyrazone helps to remove excess uric acid from the body. Too much uric acid can cause gout or gouty arthritis. Certain illness or medications can increase uric acid level. It can help to reduce the risk of complications (such as kidney stones) that can occur if uric acid levels in the blood are too high (hyperuricemia).It completely inhibits the reabsorption of uric acid at the proximal convoluted tubule, thereby facilitating urinary excretion of uric acid and decreasing plasma urate concentrations.
Indications
Pyrazone is indicated for the treatment of:

Chronic gouty arthritis

Intermittent gouty arthritis

Dosage & Administration
200-400 mg daily in two divided doses, with meals or milk, gradually increasing when necessary to full maintenance dosage in one week.
Side Effects
The symptoms are upset stomach, vomiting, loss of appetite and joint pain. If you experience any of the following symptoms like difficulty in breathing, tightness in the chest, skin rash, unusual bleeding, fever, sore throat and mouth sores, call your doctor immediately.
Precautions
Patients receiving Pyrazone should be kept under close medical supervision and periodic blood counts are recommended. It may be administered with care to patients with a history of healed peptic ulcer. It is suggested that Pyrazone should be used with caution in conjunction with sulfa drugs, the sulfonylurea hypoglycemic agents and insulin. Because Pyrazone is a potent uricosuric agent, it may precipitate urolithiasis and renal colic, especially in the initial stages of therapy. For this reason, an adequate fluid intake and alkalinization of the urine are recommended. Salicylates antagonize the uricosuric action of Pyrazone and for this reason, their concomitant uses are contraindicated in gouty arthritis.
Contraindications
Patients with an active peptic or symptoms of gastro-intestinal inflammation or ulceration should not receive the drug. The drug is contraindicated in patients with a history or the presence of hypersensitivity to phenylbutazone or other pyrazoles.
Use in Pregnancy & Lactation
Pyrazone is in the FDA pregnancy category C. This means that it is not known whether Pyrazone will harm an unborn baby. Don't take Pyrazone without first talking to your doctor if you are pregnant.
It is also not known whether Pyrazone passess into breast milk. Do not take it without first talking to your doctor if you are breast-feeding a baby.
Overdose
Symptoms:
Nausea, vomiting, diarrhea, epigastric pain, laboured respiration, convulsions and coma. Treatment:
No specific antidote. Induce emesis, gastric lavage, supportive treatment (intravenous glucose infusions).
Commercial Packaging
Pyrazone : Each box contains 2 strips of 10 Tablets.
Others
Maintenance:
400 mg daily, given in two divided doses, as above. This dosage may be increased to 800 mg daily, if necessary and may sometimes be reduced to as low as 200 mg daily after the blood urate level has been controlled.
Products from the same therapeutic group
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Alurol
Allopurinol tablet
Febustat
Febuxostat 40 and 80 mg tablet
 
 

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