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Olanap (Olanzapine)
Therapeutic Group: Drugs of Nervous System » Anti Psychotic
Presentation

Olanap 5: Each tablet contains Olanzapine INN 5 mg.

Olanap 10: Each tablet contains Olanzapine INN 10 mg.

Descriptions
Olanzapine is a selective monoaminergic antagonist with high affinity binding to Serotonin 5-HT, Dopamine, muscarinic, H1 and alpha receptors. It has weak binding affinity to GABA-A, benzodiazepine and beta adrenergic receptors.
Indications
Schizophrenia

Prevention of Bipolar Disorder

Mania
Dosage & Administration
Schizophrenia, combination therapy for Mania, Bipolar Disorder:
The initial dose is 5-10 mg once daily. Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5-20 mg daily. Dosage greater than 10 mg daily only after reassessment. Maximum dose is 20 mg daily.
Monotherapy for Mania:
Initially 15 mg once daily. Daily dosage may subsequently be adjusted on the basis of individual clinical status within the range of 5-20 mg daily. Dosage greater than 15 mg only after reassessment. Maximum dose is 20 mg daily.
Olanzapine can be given without regard to meals. Gradual tapering of the dose should be considered while discontinuing Olanzapine.
Side Effects
Very common undesirable effects are somnolence and weight gain. Besides increased appetite, elevated glucose levels, elevated triglyceride levels, dizziness, akathisia, Parkinson's disease, dyskinesia, orthostatic hypotension, mild and transient anticholinergic effects including constipation and dry mouth, asthenia, edema and photosensitivity reaction etc. may be observed.
Precautions
Precaution should be taken in case of impaired renal, hepatic, cardiovascular, cerebrovascular and respiratory failure, prostatic hypertrophy, paralytic ileus, diabetes mellitus, Parkinson's disease and in pregnancy.
Contraindications
Hypersensitivity to the active substance or to any of the excipients. Patients with known risk for narrow-angle glaucoma.
Use in Pregnancy & Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant women.
Lactation: Olanzapine is excreted in breast milk. Patients should be advised not to breast-feed an infant if they are taking Olanzapine.
Drug Interaction
Olanzapine may antagonize the effects of levodopa and dopamine agonists. Drugs that induce CYP1A2 or glucoronyl transferase enzymes e.g, Omeprazole and Rifampicin, may increase Olanzapine clearance. Inhibitors of CYP1A2 may potentially inhibit Olanzapine elimination. Carbamazepine may increase the clearance of Olanzapine. Concomitant administration of activated charcoal reduces the oral bioavailability of Olanzapine by 50-60%. Caution should be taken when Olanzapine is administered with centrally acting drugs and alcohol.
Commercial Packaging
Olanap 5: Each box contains 5 strips of 10 Tablets.
Olanap 10: Each box contains 5 strips of 10 Tablets.
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