Home > Products > Epleron
Share Print This Page

Epleron (Eplerenone)
Therapeutic Group: Cardiovascular » Anti Hypertensive » Diuretic
Presentation
Epleron

Epleron 25: Each tablet contains Eplerenone INN 25 mg.

Descriptions
Eplerenone is a blocker of aldosterone binding at the mineralocorticoid receptor. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone-system (RAAS). Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone and potassium.Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g. kidney) and nonepithelial (e.g. heart, blood vessels, and brain) tissues and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms. Eplerenone has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of Eplerenone.
Indications
*Congestive Heart Failure after an acute Myocardial Infarction

*Hypertension.
Dosage & Administration
Congestive Heart Failure after an acute Myocardial Infarction:
The recommended dose of Eplerenone is 50 mg once daily. Treatment should be initiated at 25 mg once daily and titrated to the target dose of 50 mg once daily preferably within 4 weeks as tolerated by the patient. Eplerenone may be administered with or without food.
Hypertension:
Eplerenone may be used alone or in combination with other antihypertensive agents. The recommended starting dose of Eplerenone is 50 mg administered once daily. For patients with an inadequate blood pressure response to 50 mg once daily the dosage of Eplerenone should be increased to 50 mg twice daily. Higher dosages of Eplerenone are not recommended either because they have no greater effect on blood pressure than 100 mg or because they are associated with an increased risk of hyperkalemia.
Side Effects
Headache, dizziness, diarrhea, stomach pain, nausea, cough or flu-like symptoms may occur. Symptoms of a serious allergic reaction like: rash, itching, swelling, severe dizziness, trouble breathing can occur.
Precautions
Eplerenone should be used with caution in hyperkalemia, severe kidney disease, diabetic patients with Congestive Heart Failure after an acute Myocardial Infarction including those with proteinuria.
Contraindications
Eplerenone is contraindicated in-
• Hyperkalaemia
• Severe renal impairment (creatinine clearance less than 30 ml/min)
• Severe hepatic impairment
• Concomitant use with potent CYP3A4 inhibitors like Ketoconazole, Itraconazole, Nefazodone, Troleandomycin, Clarithromycin, Ritonavir, and Nelfinavir or other
• Potassium-sparing diuretics are also contraindicated
Use in Pregnancy & Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant
women. Eplerenone should be used during pregnancy only if the potential benefit justifies the
potential risk to the fetus.
Nursing Mothers: The concentration of Eplerenone in human breast milk after oral administration is unknown. Because many drugs are excreted in human milk and because of the unknown potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Overdose
No cases of human overdosage with Eplerenone have been reported.
Commercial Packaging
Epleron 25: Each box contains 2 blister strips of 10 tablets.
Others
Pediatric use: The safety and effectiveness of Eplerenone have not been established in pediatric patients.

Geriatric use: No differences in overall incidence of efficacy or safety was observed in elderly patients.
Products from the same therapeutic group
Cardiovascular
Anti Anginal
Angifix
Isosorbide-5-Mononitrate
Feelnor
Trimetazidine Dihydrochloride tablet
Ivaprex
Ivabradine Hydrochloride
Ralozine
Ranolazine 500 mg
Trocer
Nitroglycerin 2.6 mg Capsule & Tablet
Trocer Spray
Nitroglycerin 0.4 mg Spray
Anti Coagulant
Parinox
Enoxaparin Sodium BP
Roxarel
Rivaroxaban 10 & 15 mg Tablet
Warin
Warfarin tablet
Anti Fibrinolytic
Intrax
Tranexamic acid BP
Anti Hypertensive
ARB Plain
Osartil
Losartan Potassium Tablet
Valsartil
Valsartan tablet
Xyotil
Olmesartan Medoxomil 20 & 40 mg Tablet
ACE Inhibitor Plain
Ramoril
Ramipril tablet
ACE Inhibitor Combination
Benadip
Benazepril plus Amlodipine
Indapril
Indapamide and Perindopril Erbumine
Ramoril Plus
Ramipril & Hydrochlorothiazide Tablet
β-Blocker
Carvista
Carvedilol 6.25, 12.5 & 25 mg tablet
Presonil
Metoprolol tartrate
Bisopro
Bisoprolol Fumarate 2.5 & 5 mg Tablet
Calcium Channel Blocker
Larcadip
Lercanidipine Hydrochloride film-coated tablet
Veracal
Verapamil hydrochloride
Amlotab
Amlodipine tablet
Lacidip
Lacidipine 2 mg & 4 mg Tablet
Centrally Acting Antihypertensive
Sardopa
Methyldopa
Combined Antihypertensive Preparations
Fixocard
Amlodipine plus Atenolol tablet
Osartil Plus
Losartan Potassium & Hydrochlorothiazide Tablet
Amlosartan
Amlodipine & Valsartan tablet
Valsartil Plus
Valsartan & Hydrochlorothiazide tablet
Xyotil Plus
Olmesartan Medoxomil plus Hydrochlorothiazide
Bisopro Plus
Bisoprolol fumarate and Hydrochlorothiazide tablet
Diuretic
Acuren
Hydrochlorothiazide tablet
Edeloss
Frusemide & Spironolactone Tablet
Idatix
Indapamide 1.5 mg Tablet
Epleron
Eplerenone 25 mg Tablet
Inospiron
Spironolactone 25 mg Tablet
Bumecard
Bumetanide 1 mg, 5 mg Tablet and 2 mg/4 ml IV/IM Injection
Anti Platelet
Integril
Eptifibatide INN
Lopirel
Clopidogrel tablet
Lopirel Plus
Clopidogrel & Aspirin Tablet
Prasurel
Prasugrel Hydrochloride INN tablet
Ticarel
Ticagrelor 90 mg Tablet
Lipid Lowering
Ezetim
Ezetimibe Tablet
Nicosit
Inositol nicotinate tablets
Nofiate
Fenofibrate Capsule
Ridel  ER
Niacin USP 500 mg Extended Release tablet
Rocovas
Rosuvastatin 5 & 10 mg Tablet
Syncard
Atorvastatin 10 mg and Amlodipine 5 mg
Tiginor
Atorvastatin 10, 20 & 40 mg tablet
Sympathomimetics / Inotropes
Adrinor
Adrenaline 1 mg/ml IV, IM, SC injection
Dobutin
Dobutamine Hydrochloride USP
Myomine
Dopamine Hydrochloride BP Injection
 
 

Other christian louboutin outlet collection comes in mermaid shoes cut. There are two samples of louboutin sneakers shown in the pictures. Both shoes are different indeed with stylish and creative details on certain areas such as skirt, waist and chest. To match the latest christian louboutin model, these mermaid cut wedding shoes a la princess of fairytale apply sweetheart strapless neckline cut. Thick ruffle details are applied on the first louboutin schuhe. The ruffle application is combined with pleated details on the louboutin shoes uk. Thus, in conclusion, the christian louboutin schuhe is extremely very marvelous for your modern fairytale bridal. Women always like louboutin. Sometimes, you will find louboutin damen schuhe online. But they are high quality louboutin schuhe deutschland. Best louboutin schuhe outlet for girls. The 1:1 christian louboutin are also perfect. Luxury louboutin schoenen for sale online.