Anestho 500 IV Injection: Each vial contains Thiopental Sodium for Injection USP 500 mg (a sterile mixture of Thiopental Sodium and anhydrous Sodium Carbonate as a buffer).
Anestho 1 gm IV Injection: Each vial contains Thiopental Sodium for Injection USP 1 gm (a sterile mixture of Thiopental Sodium and anhydrous Sodium Carbonate as a buffer).
Approximately 80% of the drug in the blood is bound to plasma protein. Thiopental Sodium is largely degraded in the liver and to a smaller extent in other tissues, especially the kidney and brain. It has a pKa of 7.4; Biotransformation products of Thiopental are pharmacologically inactive and mostly excreted in the urine.
Premedication usually consists of atropine or scopolamine to suppress vagal reflexes and
inhibit secretions. In addition, a barbiturate or an opiate is often given. Ideally, the peak effect of these medications should be reached shortly before the time of induction.
It is advisable to inject a small "test" dose of 25 mg to 75 mg of Thiopental Sodium for Injection to assess tolerance or unusual sensitivity to Thiopental Sodium for Injection, and pausing to observe patient reaction for at least 60 seconds. If unexpectedly deep anesthesia develops or if respiratory depression occurs, consider these possibilities: (1) the patient may be unusually sensitive to Thiopental Sodium for Injection, (2) the solution may be more concentrated than had been assumed, or (3) the patient may have received too much.
Use in anaesthesia
Normal dosage for the induction of anesthesia is 100 mg to 150 mg injected over 10 to 15 seconds. If necessary, a repeat dose of 100 mg to 150 mg may be given after one minute. No fixed dosage recommendations for the intravenous injection can be given, since the dosage will need to be carefully adjusted according to the patient's response. Factors such as age, sex, and weight of the patient should be taken into consideration. Thiopental Sodium reaches effective concentrations in the brain within 30 seconds and anesthesia is normally produced within one minute of an intravenous dose.
100 mg to 150 mg intravenously over 10 to 15 seconds, normally as a 2.5% w/v solution.
A repeat dose of 100 mg to 150 mg may be given after one minute. The intravenous injection should be given slowly and the amount given titrated against the patient's response to minimize the risk of respiratory depression or the possibility of over dosage. The average dose for an adult of 70 kg is roughly 200 mg to 300 mg (8 mls to 12 mls of a 2.5% w/v solution) with a maximum of 500 mg.
2 mg/kg to 7 mg/kg bodyweight, intravenously over 10 to 15 seconds, normally as a 2.5% w/v solution. A repeat dose of 2 mg/kg to 7 mg/kg may be given after one minute. The dose is 2 mg/kg to 7 mg/kg based on the patient's response. The dose for children should not exceed 7 mg/kg.
Smaller adult doses are advisable.
Use in convulsive states
75 mg to 125 mg (3 mls to 5 mls of a 2.5% w/v solution) should be given as soon as possible after the convulsion begins. Further doses may be required to control convulsion following the use of a local anesthetic. Other regimens, such as the use of intravenous or rectal diazepam, may be used to control convulsive states.
This product may be habit forming. Keep resuscitative and endotracheal intubation equipment and oxygen readily available. Maintain patency of the airway at all times. Only persons qualified in the use of anesthetics should administer this drug. Avoid extravasations or intra-arterial injection.
Solutions should be freshly prepared and used immediately. Any portion of the contents remaining should be discarded.
Anestho 1 gm injection: Each box contains 1 vial of 1 gm Thiopental Sodium USP for Injection (a sterile mixture of Thiopental Sodium and anhydrous Sodium Carbonate as a buffer) & 2 ampoules of 10 ml Water for Injection BP.