Intrax Capsule: Each capsule contains Tranexamic acid BP 500 mg.
Intrax Injection: Each 5 ml ampoule contains Tranexamic acid BP 500 mg.
Tranexamic acid is rapidly absorbed from the gastrointestinal tract. Maximum serum levels are reached within 2-3 hours. After oral administration, about 40% of the dose is excreted in the urine during the first 24 hours. After intravenous administration, 45% of the dose is excreted in the urine during the first day.
Prostatectomy and bladder surgery
Conisation of the cervix
Management of dental extraction in patients with coagulopathies
General fibrinolysis as in prostatic and pancreatic cancer, after thoracic and other major surgery, in obstetrical complications such as abruptio placentae and post-partum haemorrhage, in leukaemia and liver diseases and in connection with thrombolytic therapy with streptokinase.
Hereditary angioneurotic oedema.
1-1.5 gm orally three to four times daily for three to four days.
5-10 ml by slow intravenous injection every eight hours (the first injection being given during the operation) for the first three days after surgery; thereafter 1-1.5 gm orally three to four times daily until macroscopic haematuria is no longer present.
1.5 gm orally three times daily for four to ten days. Intrax injection may be applied topically to the nasal mucosa of patients suffering from epistaxis. This can be done by soaking a gauze strip in the solution, and then packing the nasal cavity.
1-1.5 gm orally 2-3 times daily until macroscopic haematuria is no longer present.
Conisation of the cervix
1.5 gm orally 3 times a day for 12 to 14 days post-operatively.
Dental surgery in patients with coagulopathies
Immediately before surgery, 10 mg per kg body-weight should be given intravenously. After surgery, 25 mg per kg body-weight are given orally three to four times daily for six to eight days. Coagulation factor concentrate might be necessary to administrate.
1.0 gm (10 ml) by slow intravenous injection three to four times daily. With fibrinolysis in conjunction with diagnosed, increased intravascular coagulation i.e. defibrillation syndrome, an anticoagulant such as heparin may be given with caution.
Hereditary angioneurotic oedema
1-1.5 gm orally two to three times daily as intermittent or continuous treatment depending on whether the patient has prodromal symptoms or not.
For patients with impaired renal function, the following dosages are recommended:
Serum creatinine Dose IV Dose Orally Dose frequency
120-249 10mg/kg 15 mg/kg twice daily
250-500 10 mg/kg 15 mg/kg daily
>500 5 mg/kg 7.5mg/kg daily
Oral dose: 25 mg/kg 2 to 3 times daily for 7 to 10 days.
Injection: 10 mg/kg 6 to 8 hours for 7 to 10 days.
Patients with disseminated intravascular coagulation (DIC), who require treatment with it must be under the strict supervision of a physician experienced in treating this disorder.
In the long-term treatment of patients, regular eye examination should be performed. If a colour vision disorder occurs during the course of treatment, the drug should be discontinued.
Pharmaceutical precautions: Intrax injection should not be mixed with blood for transfusion or infusion solutions containing penicillin.
Hypersensitivity to tranexamic acid or any of the ingredients
Lactation: Tranexamic acid is excreted into breast milk, but it is not likely to influence the child at therapeutic doses.
Treatment of overdosage: If justified, initiate vomiting, then gastric lavage, charcoal therapy and symptomatic treatment. Maintain adequate diuresis.
Intrax Injection: Each box contains 1 blister strip of 5 ampoules.