Home > Products > Fenazine
Share Print This Page

Fenazine (Fluphenazine Decanoate)
Therapeutic Group: Drugs of Nervous System » Anti Psychotic
Presentation
Fenazine

Fenazine IM/SC injection: Each 1 ml ampoule contains sterile 25 mg of Fluphenazine Decanoate.

Descriptions
Fluphenazine Decanoate is a phenothiazine derivative. It is a highly potent antipsychotic agent with a markedly extended duration of action, available for intramuscular or subcutaneous administration. The esterification of Fluphenazine with decanoic acid markedly prolongs the drug\'s duration of effect without reducing its activity.Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It produces calmness and reduces aggressiveness with disappearance of hallucinations and delusions.
Indications
In the long-term management of psychotic disorders including:

Schizophrenia

Mania and

Organic brain syndrome.
Dosage & Administration
Fluphenazine Decanoate by deep intramuscular injection into the gluteal muscle, test dose 12.5 mg (6.25 mg in elderly), then after 4-7 days 12.5-100 mg repeated at intervals of 14-35 days, adjusted according to response; it is not recommended for children.
Side Effects
The side effects include tardive dyskinesia, sedation, mental confusion; hypotension; hyperprolactinaemia leading to galactorrhoea and amenorrhoea in women; loss of libido, impotence and sterility in males. Also include allergic reactions, cholestatic jaundice, corneal and lens deposists, skin pigmentation. Other potential adverse reactions are agranulocytosis; neuroleptic syndrome.
Precautions
Special precaution should be practiced in presence of convulsive disorders; hepatic, renal, cerebrovascular, respiratory and cardiovascular diseases. Also precaution should be observed in case of phenochromocytoma; bone marrow suppression; elderly or debilitated patients.
Contraindications
Fluphenazine Decanoate oily Injection is contraindicated in patients with hypersensitivity to the drug. Also contraindicated in comatose or severely depressed states, blood dyscrasias, liver disease, pregnancy (3rd trimester), lactation.
Use in Pregnancy & Lactation
The safety for the use of Fluphenazine decanoate during pregnancy has not yet been established; therefore the possible hazards should be weighed against the potential benefits when administering this drug to pregnant patients.
Drug Interaction
Fluphenazine reverses antihypertensive effects of Guanethidine, Methyldopa and Clonidine. It also causes lithium toxicity by interacting with it. Antacids may reduce bioavailability of phenothiazines. Additive CNS depressant effects produced with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.
Storage
It should be kept out of the reach and sight of children. It also should be protected from light and stored below 25 °C. It should not be refrigerated or freezed.
Commercial Packaging
Fenazine IM/SC injection: Each box contains 5 ampoules of 1 ml.
Products from the same therapeutic group
Drugs of Nervous System
Anti Alzheimers
Ameloss
Donepezil Hydrochloride tablet
Remtin
Memantine Hydrochloride INN tablet
Anti Depressant
Arpolax
Citalopram tablet
Duloxen
Duloxetine Hydrochloride tablet
Esipram
Escitalopram INN 5 & 10 mg tablet
Mitaprex
Mirtazapine 7.5, 15 and 30 mg Tablet
Mitaprex
Mirtazapine
Pramin
Imipramine HCl BP 25 mg tablet
Repose
Sertraline
Tenaxit
Flupentixol-Melitracen tablet
Anti Epileptic
Barbit
Phenobarbital BP
Lamogin
Lamotrigine BP Tablet
Neurocet
Levetiracetam tablet
Valex
Sodium Valproate tablet and syrup
Valex CR
Sodium Valproate tablet/syrup
Anti Migraine
Florium
Flunarizine Dihydrochloride BP Tablet
Migrex
Tolfenamic acid BP 200 mg
Topirva
Topiramate tablets
Zomitan
Zolmitriptan tablet
Anti Parkinsons
Cyclid
Procyclidine Hydrochloride
Trihexy
Trihexyphenidyl Hydrochloride USP
Anti Psychotic
Aripra
Aripiprazole tablet
Fenazine
Fluphenazine Decanoate BP
Frenia
Risperidone tablet
Halopid
Haloperidol BP
Lithin SR
Lithium Carbonate BP 400 mg
Luradox
Lurasidone hydrochloride 20 & 40 mg Tablet
Olanap
Olanzapine
Panirid
Paroxetine Hydrochloride Hemihydrate BP Tablet
Quiet
Quetiapine Fumarate INN
Zapenia
Clozapine BP Tablet
Anti Vertigo
Menaril
Betahistine Dihydrochloride Tablet
Revert
Cinnarizine-Dimenhydrinate tablet
Anxiolytic and Tranquilizer
Disopan
Clonazepam tablet & Drops
Lozicum
Lorazepam 1 mg tablet
Siesta
Bromazepam USP 3 mg
Zolium
Alprazolam tablet
Hypnitic
Somarant
Suvorexant 10 mg Tablet
Memory Enhancer
Vinsetine
Vinpocetine 5mg Tablet
Neuropathy Neuralgia
Gabapen
Gabapentin tablet
Mecolagin
Mecobalamin
Pregaben
Pregabalin Capsule