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Fenazine (Fluphenazine Decanoate)
Therapeutic Group: Drugs of Nervous System » Anti Psychotic
Presentation
Fenazine

Fenazine IM/SC injection: Each 1 ml ampoule contains sterile 25 mg of Fluphenazine Decanoate.

Descriptions
Fluphenazine Decanoate is a phenothiazine derivative. It is a highly potent antipsychotic agent with a markedly extended duration of action, available for intramuscular or subcutaneous administration. The esterification of Fluphenazine with decanoic acid markedly prolongs the drug\'s duration of effect without reducing its activity.Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system and decreases the release of hypothalamic and hypophyseal hormones. It produces calmness and reduces aggressiveness with disappearance of hallucinations and delusions.
Indications
In the long-term management of psychotic disorders including:

Schizophrenia

Mania and

Organic brain syndrome.
Dosage & Administration
Fluphenazine Decanoate by deep intramuscular injection into the gluteal muscle, test dose 12.5 mg (6.25 mg in elderly), then after 4-7 days 12.5-100 mg repeated at intervals of 14-35 days, adjusted according to response; it is not recommended for children.
Side Effects
The side effects include tardive dyskinesia, sedation, mental confusion; hypotension; hyperprolactinaemia leading to galactorrhoea and amenorrhoea in women; loss of libido, impotence and sterility in males. Also include allergic reactions, cholestatic jaundice, corneal and lens deposists, skin pigmentation. Other potential adverse reactions are agranulocytosis; neuroleptic syndrome.
Precautions
Special precaution should be practiced in presence of convulsive disorders; hepatic, renal, cerebrovascular, respiratory and cardiovascular diseases. Also precaution should be observed in case of phenochromocytoma; bone marrow suppression; elderly or debilitated patients.
Contraindications
Fluphenazine Decanoate oily Injection is contraindicated in patients with hypersensitivity to the drug. Also contraindicated in comatose or severely depressed states, blood dyscrasias, liver disease, pregnancy (3rd trimester), lactation.
Use in Pregnancy & Lactation
The safety for the use of Fluphenazine decanoate during pregnancy has not yet been established; therefore the possible hazards should be weighed against the potential benefits when administering this drug to pregnant patients.
Drug Interaction
Fluphenazine reverses antihypertensive effects of Guanethidine, Methyldopa and Clonidine. It also causes lithium toxicity by interacting with it. Antacids may reduce bioavailability of phenothiazines. Additive CNS depressant effects produced with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.
Storage
It should be kept out of the reach and sight of children. It also should be protected from light and stored below 25 °C. It should not be refrigerated or freezed.
Commercial Packaging
Fenazine IM/SC injection: Each box contains 5 ampoules of 1 ml.
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