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Drotapan (Drotaverine)
Therapeutic Group: Anti Spasmodic

Drotapan tablet: Each tablet contains Drotaverine HCl INN equivalent to Drotaverine 40 mg.

Drotaverine is a spasmolytic agent which acts directly on smooth muscle cells by adsorption on the cell surface. Drotaverine inhibits the phosphodiesterase enzyme which leads to an increase of the cAMP level producing smooth muscle cell relaxation. It is thought that Drotaverine also inhibits the initial calcium uptake of the cell. Drotaverine is characterized by a rapid onset of action which is very advantageous in cases of acute painful spastic conditions. Because of its direct action on smooth muscle, Drotaverine does not affect the autonomic nervous system. Therefore Drotaverine is free of the side effects associated with anticholinergic antispasmodics and can be used in glaucoma and prostatic hypertrophy. In addition to its spasmolytic and vasodilatory actions, Drotaverine elicits a selective blockade of cardiac beta receptors.
Spastic conditions of the gastrointestinal tract, irritable bowel syndrome.

Biliary colics and spastic conditions of the biliary tract: Cholecystolithiasis, cholecystitis, cholangitis.

Renal colics and spastic conditions of the urogenital tract: Nephrolithiasis, ureterolithiasis, pyelitis, cystitis.

Spastic conditions of the uterus: Dysmenorrhea, imminent abortion, uterine tetanus.

Dosage & Administration
Drotapan tablet
Adults: 1 to 2 tablets, 3 times daily.
Children (over 6 years): 1/2 to 1 tablet, 1-2 times daily.
Children (1-6 years): 1/4 to 1/2 tablet, 1-2 times daily.
Side Effects
In rare cases nausea and vomiting may occur.
Caution should be taken for patients suffering from liver and kidney disease.
Drotaverine is contraindicated in patients with known hypersensitivity to the products and its constituents.
Use in Pregnancy & Lactation
There is no known case of teratogenecity in animal studies. However, the use of drotaverine should be avoided during pregnancy and lactation.
Drug Interaction
Levodopa (anti-perkinson effect may be decreased).
Commercial Packaging
Drotapan tablet: Each box contains 10 blister strips of 10 tables
Products from the same therapeutic group
Anti Spasmodic
Dicycloverine Hydrochloride tablet, syrup and injection
Drotaverine HCl INN tablet
Tiemonium Methylsulfate

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