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Adora (Cefadroxil)
Therapeutic Group: Anti Bacterial
Presentation

Adora 500 Capsule: Each capsule contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 500 mg.

Adora Powder for Suspension: When reconstituted each 5 ml of suspension contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 125 mg.

Adora Powder for Paediatric Drops: When reconstituted each 1.25 ml contains Cefadroxil Monohydrate USP equivalent to Cefadroxil 125 mg.

Descriptions
Adora (Cefadroxil Monohydrate) is an acid-stable semi-synthetic oral antibiotic in the cephalosporin family of drugs. Cefadroxil acts by preventing bacteria from forming protective cell wall necessary for survival. It has superior pharmacokinetic profile over all first generation cephalosporins.

Indications
Adora (Cefadroxil Monohydrate) is indicated for the treatment of patients with infection caused by susceptible strains of the designated organisms in the following diseases:

*Upper respiratory tract infections caused by Streptococcus pyogenes (Group A beta-hemolytic Streptococci) and Streptococcus pneumoniae.

* Urinary tract infections caused by E. coli, Proteus mirabilis, and Klebsiella species.

* Skin and soft tissue infections caused by Staphylococci (including penicillinase producing strains) and Streptococci.



Dosage & Administration
The bioavailability and consequent chemotherapeutic effects of Cefadroxil are unaffected by foods. It may, therefore, be taken with meals or on an empty stomach. Administration with food may be helpful in diminishing potential gastrointestinal complaints occasionally associated with oral cephalosporin therapy.

IndicationAdult (dose)Children (Dose)
Upper respiratory tract Infections1 gm per day in single (q.d.) or divided doses (b.i.d.) for 10 days 12 hourly30 mg/kg/day in a single or in equally divided doses every 12 hours
Urinary Tract Infections1 or 2 gm per day in single (q.d.) or divided doses (b.i.d.)30 mg/kg/day in equally divided doses every 12 hours
For all other UTIs 2 gm per day in divided doses (b.i.d)30 mg/kg/day in equally divided doses every 12 hours
Skin & soft tissue Infections1 gm per day in single (q.d.) or divided doses (b.i.d.)30 mg/kg/day in equally divided doses every 12 hours
Prophylaxis against bacterial endocarditis2 gm 1 hour prior to the procedure50 mg/kg 1 hour prior to the procedure
Side Effects
Generally cefadroxil is well tolerated. However, the most commonly reported side effects are gastrointestinal disturbances and hypersensitivity phenomena. Side effects including nausea, vomiting, diarrhoea, dyspepsia, abdominal discomfort, fever, dizziness, headache, arthralgia may also occur.
Precautions
N/A
Contraindications
Cefadroxil is contraindicated in patients with a history of hypersensitivity to any of the ingredients.
Use in Pregnancy & Lactation
Cefadroxil (Adora) is widely used as a first-line oral antibiotic for the treatment of uncomplicated urinary tract infections in pregnant women.
Drug Interaction
There is no known clinically important drug interactions with Cefadroxil.
Overdose
If amounts >250 mg/kg is ingested, gastric lavage or simulation of vomiting is appropriate.
Commercial Packaging
Adora 500 mg Capsule : Box containing 5 Alu-Alu blister strips of 4 capsules.
Adora Powder for Suspension : Bottle containing powder to produce 100 ml suspension when reconstituted.
Adora Powder for Suspension : Bottle containing powder to produce 60 ml suspension when reconstituted.
Adora Powder for Paediatric Drops: Bottle containing powder for preparation of 15 ml suspension.
Others
Direction for Reconstitution of suspension
For 100 ml suspension and 100 ml DS suspension: Add 65 ml (13 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.
For 60 ml suspension: Add 40 ml (8 measuring spoonful) of boiled and cooled water to the dry mixture in the bottle. For ease of preparation add water to the bottle in two portions. Shake well after each addition until all the powder is in suspension.
Paediatric Drops: Add 10 ml (2 measuring spoonful) to the bottle and shake vigorously.

Note: Shake both oral suspension and paediatric drops well before each use. Keep the bottle tightly closed. The reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 14 days.
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