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Topicacin (Capsaicin)
Therapeutic Group: Analgesic, Anti Inflammatory » NSAIDs/Non Opiod Analgesic
Presentation
Topicacin

Topicacin 0.025% w/w Cream: Each gram cream contains Capsaicin USP 0.25 mg.

Descriptions
Topical Capsaicin has been used to treat different types of pain. Capsaicin renders skin insensitive to pain by depleting and preventing reaccumulation of substance P in peripheral sensory neurons. Substance P is the principal chemomediator of pain impulses from the periphery to the Central Nervous System.
Indications
Rheumatoid arthritis

Osteoarthritis

Pain due to diabetic neuropathy

Joint pain

Post-herpetic neuralgia

Post-surgical neuropathic pain

Nerve Pain

Back pain

Muscle pain

Fibromyalgia

Bursitis

Pruritis (itching)
Dosage & Administration
Persons 18 years of age and older apply a thin film of Capsaicin cream to affected area 3 to 4 times daily. A burning sensation may occur upon application, but generally disappears with regular use. Application schedules of 3 to 4 times a day for 2 weeks provides optimum pain relief.
Side Effects
Capsaicin may cause transient burning on application. This burning is observed more frequently when the application schedules are more than 3-4 times daily. The burning can be enhanced if too much cream is used and if it is applied just before or after a bath or shower.
Precautions
Capsaicin cream should not be applied to broken or irritated skin. Applied area should not be tightly bandaged. Do not get on mucous membranes and into eyes or on contact lenses. If this occurs, rinse the affected area thoroughly with water. Do not apply the cream on the heat treated area as this may increase the burning sensation. In case of accidental ingestion, seek physician advice immediately.
Contraindications
Capsaicin cream is contraindicated for use on broken or irritated skin or known hypersensitivity to this medication.
Use in Pregnancy & Lactation
The safety of Capsaicin during pregnancy or lactation has not been established in either humans or animals.
Overdose
Sufficient information on overdose of Capsaicin is not available.
Storage
Store at 15-30 C
Commercial Packaging
Topicacin 0.025% w/w Cream: Each tube contains 20 gm cream.
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