Prosol IV is a sterile aqueous solution, consisting of crystalline amino acids and D-sorbitol with electrolytes. Prosol IV is necessary as the nitrogen sources for parenteral nutrition in which nitrogen is provided in the form of essential and non-essential amino acids. The solution is clear, colorless having a pH lying in the range of 5.7 to 7.0.
Each 100 ml contains:
i) Active ingredients Specification Quantity
L-Isoleucine USP 0.352 gm
L-Leucine USP 0.490 gm
L-Lysine Hydrochloride USP 0.430 gm
L-Methionine USP 0.225 gm
L-Phenylalanine USP 0.533 gm
L-Threonine USP 0.250 gm
L-Tryptophan USP 0.090 gm
L-Valine USP 0.360 gm
L-Arginine Hydrochloride USP 0.500 gm
L-Histidine Hydrochloride Monohydrate BP 0.250 gm
L-Aspartic Acid USP 0.250 gm
L - Glutamic Acid BP 0.075 gm
L-Alanine USP 0.200 gm
L-Cystine BP 0.010 gm
Glycine (2-Amino Acetic Acid) BP 0.760 gm
L-Proline USP 0.100 gm
L-Serine USP 0.100 gm
L-Tyrosine USP 0.025 gm
D-Sorbitol BP 5.000 gm
Water for injection BP q.s
Energy content: 155 Kj/L (371.14 Kcal/L)
Nitrogen content: 7.2 gm/L
Prosol IV consists of 18 essential and non-essential amino acids which are needed for protein synthesis as well as body build up. The amino acid composition is such that positive nitrogen balance can be achieved in the post-operative period and during extended periods of intravenous nutrition.
The nitrogen requirement for maintenance of body protein mass depends on the patient's condition (nutritional state and degree of metabolic stress).
No or minor metabolic stress and normal nutritional state: 0.10-0.15 g nitrogen/kg/day,
Moderate metabolic stress with or without malnutrition: 0.15-0.20 g nitrogen/kg/day,
Severe catabolism as in burns, sepsis and trauma: up to 0.20-0.25 g nitrogen/kg/day.
The dosage range 0.10-0.25 g nitrogen/kg/day corresponds to 15-35 ml Prosol IV/kg/day.
In obese patients, the dose should be based on the estimated ideal weight. Depending upon patients requirements, 1000-2000 ml Prosol IV may be infused intravenously per 24 hours. Prosol IV should be infused slowly, at rates 1.4-2.8 ml (30-60 drops) per minute.
Infants and Children:
In children and infants, the rate of infusion is 28-35 ml/kg body wt/day is recommended, with a stepwise increment in the rate of administration during the first week of treatment.
Do not use if the solution is turbid or contains particles. Discard any unused portion.