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Alfasin XR (Alfuzosin)
Therapeutic Group: Urological » Anti-BPH
Presentation
Alfasin XR

Alfasin XR tablet: Each extended release tablet contains Alfuzosin Hydrochloride BP 10 mg.

Descriptions
Alfuzosin Hydrochloride is a selective antagonist of post-synaptic a1 adrenoreceptors, which are located in the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra. Alfuzosin Hydrochloride relaxes the tone of the prostate smooth muscle, prostate capsule, bladder neck and proximal urethra. It competitively and selectively binds to the post synaptic a1-adrenergic receptors in the lower urinary tract. It also relaxes sympathetic nervous stimulation, reduces resting urethral pressure and inhibits urethral hypertonia-induced sympathetic nervous stimulation. As an uroselective agent, Alfuzosin Hydrochloride preferentially binds to prostatic a1 receptors, blockage of these receptors result in reduction of BPH symptoms, improvement of urine flow and decreased potential for hypertensive events.
Indications
Alfuzosin Hydrochloride is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia(BPH), lower urinary tract symptoms (LUTS) including urinary frequency, nocturia, incomplete emptying and urinary hesitancy associated with BPH.
Dosage & Administration
The recommended dosage is one 10 mg Alfuzosin Hydrochloride tablet daily to be taken immediately after the same meal each day. The tablets should not be chewed or crushed.
Side Effects
This formulation is generally well tolerated. However the following adverse events have been reported include abdominal pain, dyspepsia, constipation, nausea, impotence, bronchitis, sinusitis and pharyngitis.
Precautions
Alfuzosin Hydrochloride should not be given to patients with moderate or severe hepatic insufficiency. Caution should be exercised when Alfuzosin is administered in patients with severe renal insufficiency. If symptoms of angina pectoris should newly appear or worsen, Alfuzosin Hydrochloride should be discontinued.
Contraindications
Alfuzosin Hydrochloride should not be used in patients with moderate or severe hepatic insufficiency, since Alfuzosin Hydrochloride blood levels are increased in these patients. It should not be co-administered with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir. Alfuzosin Hydrochloride is also contraindicated in patients known to be hypersensitive to Alfuzosin Hydrochloride or any component of Alfuzosin Hydrochloride tablets.
Use in Pregnancy & Lactation
Alfuzosin Hydrochloride is not indicated for use in pregnant and lactating mother.
Overdose
Overdose of Alfuzosin Hydrochloride should lead to hypotension; support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, then the administration of intravenous fluids should be considered. If necessary, vasopressors should then be used, and the renal function should be monitored and supported as needed.
Commercial Packaging
Alfasin XR tablet: Each box contains 6 Alu-Alu blister strips of 4 tablets.
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