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Mirolast Eye Drops (Pemirolast Potassium)
Therapeutic Group: Ophthalmic » Anti Allergic Preparations
Presentation
Mirolast Eye Drops

Each ml contains Pemirolast Potassium INN 1 mg (0.1%).

Descriptions
Mirolast is a sterile, aqueous ophthalmic solution of Pemirolast Potassium. Pemirolast Potassium is a mast cell stabilizer that inhibits the invivo Type-1 immediate hypersensitivity reaction. The drug has been observed to block antigen-stimulated calcium ion influx into mast cells. Invitro and invivo studies have demonstrated that Pemirolast inhibits the antigen-induced release of inflammatory mediators (e.g., histamine, leukotriene C4, D4, E4) from human mast cells.



Pemirolast also inhibits the chemotaxis of eosinophils into ocular tissue and prevents inflammatory mediator release from human eosinophils.
Indications
Pemirolast ophthalmic solution is indicated for the prevention of itching of the eye due to allergic conjunctivitis.
Dosage & Administration
1 to 2 drops in each affected eye four times daily.
Side Effects
Burning of eye, dry eye, ocular discomfort, non ocular allergy, sinusitis, headache and sneezing or nasal congestion.
Precautions
To prevent contaminating the dropper tip and solution, do not touch the eyelids or surrounding areas with
the dropper tip
Keep the bottle tightly closed when not in use
Patients should be advised not to wear contact lens if their eye is red
Mirolast should not be used to treat contact lens related irritation
Patients should wait 10 minutes after applying Pemirolast before they insert contact lenses
Contraindications
Pemirolast ophthalmic solution is contraindicated in patients with previously demonstrated hypersensitivity to any of the ingredients of this product.
Use in Pregnancy & Lactation
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Pemirolast ophthalmic solution should be used during pregnancy only if the benefit outweighs the risk.
Lactation: It is not known whether Pemirolast Potassium is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Pemirolast ophthalmic solution is administered to a nursing woman.

Pediatric Use
Safety and effectiveness in pediatric patients below the age of 3 years have not been established.
Overdose
No information is available regarding the occurrence of overdose with ophthalmic preparations of Pemirolast.
Storage
Store at 15-25° C.
Keep out of reach of children.
Do not use more than 4 weeks after opening
Commercial Packaging
Plastic dropper bottle containing 10 ml eye drops.
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