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Actidex (Dexketoprofen)
Therapeutic Group: Analgesic, Anti Inflammatory » NSAIDs/Non Opiod Analgesic
Presentation
Actidex

Each tablet contains Dexketoprofen Trometamol equivalent to Dexketoprofen INN 25 mg.

Descriptions
Dexketoprofen belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of chemicals in the body called prostaglandins. Prostaglandins are produced in response to injury or certain diseases and would otherwise go on to cause swelling, inflammation and pain. By blocking cyclo-oxygenase, dexketoprofen prevents the production of prostaglandins and therefore reduces inflammation and pain.
Indications
Symptomatic treatment of pain of mild or moderate intensity, such as musculo-skeletal pain, menstrual pain, toothache.
Dosage & Administration
The dose of Dexketoprofen is 12.5 mg every 4-6 hours daily or 25 mg every 8 hours daily. The maximum dose is 75 mg daily. For elderly people maximum dose is 50 mg daily. Not recommended for children.
Side Effects
As with all medicines, Dexketoprofen may cause some unwanted effects in some patients. These are described below and are characteristic of non steroidal anti-inflammatory drugs:

- Common (1 - 10%): nausea, vomiting, diarrhoea, stomach pain or heartburn.

- Uncommon (0.1 - 1%): sleep disorders, nervousness, headache, dizziness,vertigo, palpitations, constipation, dry mouth, flatulence, skin rash, fatigue, hot flushes, shivering, general malaise.

- Rare (0.01-0.1%): stomach ulceration, gastric haemorrhage or perforation, pins and needles, high blood pressure, water retention, slowed breathing rate, increased hepatic enzymes, increased sweating.

- Very rare / isolated cases (<0.01%): blurred vision, ringing in the ear, low blood pressure, haematological reactions, hepatic or renal damage, dermatological and photosensitivity reactions, bronchospasm or anaphylaxis.

- In patients with systemic lupus erythematosus or mixed connective tissue disease, anti-inflammatory medicines may rarely cause isolated cases of fever, headache and rigidity of the nape (back of the neck).
Precautions
The medicine should be used with caution in conditions mentioned below:
- Allergic to any other medicines.
- Kidney disease, liver disease, heart disease or fluid retention conditions.
- Blood disorder, systemic lupus erythematosus or mixed connective tissue disease.
Contraindications
Dexketoprofen tablets are not recommended to use in patients who are:

- Allergic to this product or any of its components, aspirin or other non-steroidal anti-inflammatory medicines.

- Have suffered attacks of asthma, bronchospasm, acute rhinitis, nasal polyps, urticaria, angioedema (swollen face, eyes, lips, or tongue, or difficulty in breathing), after taking aspirin or other non-steroidal anti-inflammatory medicines.

- Have or have previously suffered from a peptic ulcer or chronic gastro-intestinal disorders.

- Have had previously gastro-intestinal haemorrhage (bleeding).

- Have suffered from bronchial asthma.

- Have severe heart failure, moderate to severe renal dysfunction or severely impaired hepatic function.

- Have a bleeding disorder, a blood clotting disorder or taking an anticoagulant.

- Pregnant or breast-feeding.
Use in Pregnancy & Lactation
Do not use during pregnancy or breast-feeding.

Should not be given to children.
Commercial Packaging
Actidex: Each box contains 5 blister strips of 10 Tablets.
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