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Nyclobate (Clobetasol)
Therapeutic Group: Skin » Steroid Plain
Presentation

Nyclobate Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w).

Nyclobate Ointment: Each gram ointment contains Clobetasol Propionate BP 0.5 mg (0.05% w/w).

Nyclobate Scalp Application: Each gram lotion contains Clobetasol Propionate BP 0.5 mg (0.05% w/w).

Nyclobate Shampoo: Each gram shampoo contains Clobetasol Propionate BP 0.5 mg (0.05% w/w).

Descriptions
Clobetasol Propionate is a highly active corticosteroid with topical anti-inflammatory activity. The major effect of Clobetasol Propionate on skin is a non-specific anti-inflammatory response, partially due to vasoconstriction and decrease in collagen synthesis.
Indications
• Eczema unresponsive to weak steroid cream or ointment

• Other inflammatory skin disorders resistant to treatment with weaker steroid creams or ointment

• Psoriasis.
Dosage & Administration
Nyclobate Cream & Ointment
Adults and children over 1 year:
• Apply sparingly to cover the affected area, and gently rub into the skin. Frequency of application is 2 to 3 times daily according to the severity of the condition. The total dose applied should not exceed 50 g weekly.
• Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient\\\'s condition being reviewed.
• Repeated short courses of Clobetasol may be used to control exacerbations

Children below 1 year: Under 1 year this preparation is not recommended
Nyclobate Scalp Application
• It should be applied to the affected scalp areas twice daily, once in morning and once at night.
• Total dosage should not exceed 50 ml per week.
• As with other highly active topical steroid preparations, therapy should be discontinued when control is achieved
Children: Under 1 year this preparation is not recommended.

Nyclobate Shampoo
• It should be applied to the dry (not wet) scalp once a day to the affected areas only.
• It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing.
• Treatment should be limited to 4 consecutive weeks.
• Total dosage of shampoo should not exceed 50 g per week.
• Under 18 years this preparation is not recommended.
Side Effects
Generally this preparation is well tolerated. However, few side effects after prolonged and intensive treatment may cause local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels, particularly when occlusive dressings are used, or when skin folds are involved.
Precautions
Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion. If used in childhood, or on the face, courses should be limited to 5 days and occlusion should not be used. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye. If used in psoriasis careful patient supervision is important.
Scalp Application: Keep away from eye. Flammable. Do not use or dry the hair near a fire or flame.
Scalp Shampoo: Do not use on areas other than the scalp. Keep away from eye.
Contraindications
It is contraindicated in rosacea, acne vulgaris, perioral dermatitis, primary cutaneous viral infections (eg. herpes simplex, chickenpox), otitis externa with a perforated eardrum, hypersensitivity to the preparations. Scalp application is contraindicated in infection of the scalp.
Use in Pregnancy & Lactation
Pregnancy category C: The safe use of this preparation during pregnancy & lactation has not been established.
Drug Interaction
No hazardous interactions have been reported with use of Clobetasol Propionate.
Overdose
Acute overdosage is very unlikely to occur, however, in the case of chronic overdosage or misuse the features of hypercortisolism may appear and in this situation topical steroids should be discontinued gradually.
Commercial Packaging
Nyclobate Cream: Each tube contains 10 gm or 20 gm cream.
Nyclobate Ointment: Each tube contains 10 gm or 20 gm ointment.
Nyclobate Scalp Application: Each bottle contains 30 ml of lotion.
Nyclobate Shampoo: Each bottle contains 60 ml of shampoo.
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Nyclobate
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