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Nicosit (Inositol Nicotinate)
Therapeutic Group: Cardiovascular » Lipid Lowering
Presentation
Nicosit

Nicosit 500: Each tablet contains Inositol nicotinate BP 500 mg.

Nicosit 750: Each tablet contains Inositol nicotinate BP 750 mg

Descriptions
Nicosit tablet is a preparation of Inositol nicotinate. It is the hexanicotinic acid ester of meso-inositol, also called inositol hexaniacinate (IHN) or inositol hexanicotinate or inositol nicotinate. The compound consists of six molecules of nicotinic acid and one molecule of inositol. Pharmacokinetic studies have indicated that these esters are absorbed intact and hydrolyzed in the body with release of free niacin and Inositol. It has been proven effective at lowering VLDL, LDL and total cholesterol and triglyceride levels while raising HDL levels. Niacin is vital to cellular metabolism. Due to its vasodilatory effects, niacin has been prescribed for the treatment of cardiovascular disease, particularly the hyperlipidemias.
Indications
Nicosit has a fairly broad range of therapeutic applications. The most well researched conditions include the hyperlipidemias, Raynaud's disease and intermittent claudication. Promising applications, which bear further investigation, include its use for stasis ulcers, dysmenorrhea, dermatitis herpetiformis, alcoholism, diabetes, cancer prevention and hypertension.
Dosage & Administration
Recommended dosage for lipid-lowering and improving conditions related to peripheral vascular insufficiency ranges from 1500 mg to 4 grams daily, in divided dosages of two to three times daily.
Side Effects
The most common side effects are headache, rash, paraesthesia, dizziness, nausea and vomiting, flushing, excessive fluid retention in the body tissues, postural hypotension, fainting
Precautions
Cautions should be exercised in patients with angina not well controlled by medical treatment and decreased blood supply through the vessels of the brain (cerebrovascular insufficiency).
Contraindications
Inositol nicotinate is contraindicated to children, early stage of stroke & people who have recently had a heart attack. It should not be used if anyone is allergic to one or any of its ingredients
Use in Pregnancy & Lactation
Pregnancy: There is no information available about the safety of this medicine during pregnancy, therefore it is not recommended for use during pregnancy, unless considered essential by your doctor. Seek medical advice from your doctor.
Lactation: There is no information available regarding the safety of this medicine during breastfeeding
Overdose
Both acute and chronic toxicities have been reported from the use of highdose niacin. Reactions to niacin range from acute symptoms of flushing, pruritis, and GI complaints to chronic symptoms of hepatotoxicity, hyperuricemia, and impaired glucose tolerance. On the other hand, no adverse effects have been reported from the use of inositol hexaniacinate in dosages as high as four grams daily
Commercial Packaging
Nicosit 500: Each box contains 5 Alu-Alu blister strips of 4 tablets.
Nicosit 750: Each box contains 5 Alu-Alu blister strips of 4 tablets
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