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Intobac Eye Drops (Tobramycin)
Therapeutic Group: Ophthalmic » Antibacterial Preparations
Presentation
Intobac Eye Drops

Intobac 0.3% eye drops: Each ml contains Tobramycin USP 3 mg.

Descriptions
Intobac is a broad-spectrum, aminoglycoside antibiotic of bacteriocidal type of action.

It works by inhibition of bacterial protein synthesis by binding to the 30S subunit of the bacterial ribosome.
Indications
Intobac eye drops is a topical antibiotic indicated in treatment of external bacterial infections of the eye and its adnexa caused by susceptible organisms:

Gram-positive microorganisms:

Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae,

Streptococcus sp. of group A beta-hemolytic and some nonhemolytic species.

Gram-negative microorganisms:

Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella sp., Proteus mirabillis, Proteus vulgaris, Haemophilus influenzae, Morganella morganii, some strains of Neisseria, Acinetobacter calcoaceticus, Providentia, Serratia, Salmonella sp.
Dosage & Administration
Adults: If the infection is mild to moderate, 1 or 2 drops into the affected eye(s) every 4 hours. In severe infections, 2 drops into the eye(s) every hour until there is improvement ,following which treatment should be reduced prior to discontinuation.
Pediatric Use: Safety and effectiveness in pediatric patients below the age of 2 months has not been established.

Side Effects
Localized ocular toxicity and hypersensitivity, including lid itching and swelling, conjunctival erythema and lacrimation
Precautions
Sensitivity to topically applied aminoglycosides may occur in some patients. If a sensitivity reaction to tobramycin occurs, discontinue use. Prolonged use may lead to skin sensitisation or result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs appropriate therapy should be initiated
Contraindications
Tobramycin eye drops is contraindicated in patients hypersensitive to tobramycin or
to any of the ingredients of the formulation.
Use in Pregnancy & Lactation
Pregnancy Category B. Reproduction studies in three types of animals at doses up to thirty-three times the normal human systemic dose have revealed no evidence of impaired fertility or harm to the fetus due to tobramycin. There are, however, no adequate and well-controlled studies in pregnant women. Because animal studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Overdose
Signs and symptoms of overdose may be similar to side effects as described above
Storage
Protect from light.
Store below 25 °C.
Keep out of reach of children.
Do not use more than 4 weeks after opening
Commercial Packaging
Intobac 0.3% eye drops: Each plastic dropper bottle containing 5 ml eye drops
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