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I-guard Eye/Ear Drops (Chloramphenicol)
Therapeutic Group: Ophthalmic » Antibacterial Preparations
I-guard Eye/Ear Drops

I-guard sterile eye/ear drops: Each ml contains 5 mg of Chloramphenicol BP.

I-guard contains ChIoramphenicol which is a broad spectrum bacteriostatic antibiotic. It is effective against wide range of Gram-positive and Gram-negative bacteria, cocci and large viruses. ChIorarnphenicol is usually well tolerated and is well penetrated in non-inflammed eye better than any other antibiotic regardless of the mode of administration, resistance is slow to develop, moderate in nature and not necessarily permanent.
I-guard Eye/Ear Drop is used in Chloramphenicol susceptible organisms in infected eyelid, cornea (corneal ulcer), conjunctiva, lachrymal canal system and anterior of the uvea. It may also be used in Trachoma, Zoster and Parinauds conjunctivitis. It is used as an adjuvant therapy with other drugs in the treatment of herpes simplex and for the prophylaxis of bacterial infection before and after surgical operation and after fire and chemical burns. It is beneficial in rinsing the lachrymal canal as a preventive and curative of infections. Chloramphenicol can inhibit or destroy the bacteria present in ear canal.
Dosage & Administration
For Eye
Adults, children and infants (all age groups): One or two drops 4 to 6 times a day should be placed in the infected eyes. If necessary the frequency of dose can be increased. Treatment should be continued for approximately 7 days but should not be continued for more than three weeks without re-evaluation by the prescribing physician.
For Ear
2 to 3 drops into ear canal thrice or four times daily.
Side Effects
The use of chIoramphenicol alone in Ionger period or frequent intermittent use may result occasional stinging, itching and in rare cases allergic eyelid eczema in some patients.
Prolonged use of antibiotic may result in over growth of non-susceptible organisms and fungi. This medicine should not be used regularly in prolonged period of times. If new infections appear during medication, the drug should be discontinued and appropriate measures should be taken.
Chloramphenicol Eye/Ear Drops is contraindicated in patients with hypersensitivity to it.
Use in Pregnancy & Lactation
Pregnancy: This medicine should be used with caution during pregnancy, and only if the expected benefit to the mother is greater than any possible risk to the fetus.

Lactation: This medicine should be used with caution by breastfeeding mothers, and only if the expected benefit to the mother is greater than any possible risk to the baby.
Drug Interaction
There may be some absorption of Chloramphenicol when it is used as an eye drop. If Chloramphenicol is absorbed from eye/ear drops when taking anticoagulants e.g. warfarin and nicoumalone and antidiabetics e.g. glibenclamide, there may be an increase in the effect of these medicines.

If Chloramphenicol is absorbed from eye/ear drops, when taking phenobarbital, Chloramphenicol blood levels will be decreased and when taking phenytoin, blood levels
of phenytoin will be increased.
No information is available.
Commercial Packaging
I-guard sterile eye/ear drops: Plastic dropper bottle containing 10 ml sterile eye/ear drops.
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