Home > Products > Carvista
Share Print This Page

Carvista (Carvedilol)
Therapeutic Group: Cardiovascular » Anti Hypertensive » β-Blocker

Carvista 6.25 : Each film coated tablet contains Carvedilol INN 6.25 mg.

Carvista 12.5 : Each film coated tablet contains Carvedilol INN 12.5 mg.

Carvista 25 : Each film coated tablet contains Carvedilol INN 25 mg.

Carvista (Carvedilol) is a cardiovascular drug whose main pharmacological action is non-selective antagonism of β-adrenergic receptors but which also possesses appreciable α-adrenergic antagonistic activity. It also has antiproliferative properties and is a scavenger of reactive free oxidant radicals. It is used in the treatment of hypertension, angina pectoris and congestive heart failure.
Carvista (Carvedilol) is indicated for the treatment of mild or moderate {NYHA (New York Heart Association) class II or III} heart failure of ischemic or cardiomyopathic origin, in conjunction with digitalis, diuretics and ACE inhibitor, to reduce the progression of disease as evidenced by cardiovascular death, cardiovascular hospitalization, or the need to adjust other heart failure medications. Carvista (Carvedilol) may be used in patients unable to tolerate an ACE inhibitor. Carvista (Carvedilol) may be used in patients who are not receiving digitalis, hydralazine or nitrate therapy.
Dosage & Administration
In heart failure, initially 3.125 mg twice daily (with food) may be given, dose may be increased at intervals of at least 2 weeks to 6.25 mg twice daily, then to 12.5 mg twice daily, then to 25 mg twice daily. The dose may be increased to highest dose tolerated, maximum 25 mg twice daily in patients less than 85 kg body-weight and 50 mg twice daily in patients over 85 kg.
In hypertension initially 12.5 mg once daily, increased after 2 days to usual dose of 25 mg once daily; if necessary the dose may be further increased at intervals of at least 2 weeks to maximum 50 mg daily in single or divided doses.In elderly patients the initial dose of 12.5 mg daily may provide satisfactory control.
In angina pectoris the recommended dose for initiation of therapy is 12.5 mg twice daily for the first 2 days. Thereafter, the recommended dosage is 25 mg twice daily. For elderly patients, the maximum daily dose is 50 mg daily in divided doses.
Side Effects
Postural hypotension, dizziness, headache, fatigue, gastro-intestinal disturbances, bradycardia; occasionally diminished peripheral circulation, peripheral oedema and painful extremities, dry mouth, dry eyes, eye irritation or disturbed vision, impotence, disturbances of micturition, influenza-like symptoms, rarely angina, AV block, exacerbation of intermittent claudication or Raynaud's phenomenon, allergic skin reactions, exacerbation of psoriasis, nasal stuffiness, wheezing, depressed mood, sleep disturbances, paresthesia, heart failure, changes in liver enzymes, thrombocytopenia, leukopenia are also reported.
Take caution in hepatic impairment and in heart failure monitor clinical status for 2-3 hours after initiation and after increasing each dose. Before increasing dose ensure that the renal function and heart failure are not deteriorating.
Carvedilol is contraindicated in patients with NYHA class IV (New York Heart Association Class IV) decompensated cardiac failure requiring intravenous inotropic therapy, bronchial asthma or related bronchospastic conditions, second or third-degree AV block, sick sinus syndrome (unless a permanent pacemaker is in place), cardiogenic shock or severe bradycardia. Therapy is not to be initiated in severe heart failure.
Use in Pregnancy & Lactation
Carvedilol should not be used during breast-feeding, since no studies have been performed in lactating women and animal studies have shown that carvedilol is excreted in breast milk. Safety and efficacy in children have not been established with carvedilol. Carvedilol should not be used during pregnancy as no studies have been performed in this group. Animal studies have shown that carvedilol crosses the placental barrier. No information is available on safety and efficacy of Carvedilol use in neonates.
Drug Interaction
Digoxin : In normal healthy volunteers a single dose of carvedilol taken together with a single dose of digoxin resulted in significantly increased levels of digoxin 24 hour later. Patients with congestive heart failure stabilized on digoxin have been given carvedilol concomitantly without any adverse effects. Increased monitoring of digoxin is recommended when initiating, adjusting, or discontinuing the dose of carvedilol.
Rifampin : Pretreatment with rifampin resulted in a 60% decrease in Cmax and AUC.
Warfarin : Carvedilol did not alter the in vitro plasma protein binding of warfarin.
Clonidine : b-receptor antagonists potentiate the pressor reaction which may follow sudden withdrawal of treatment with clonidine although, in theory, the a-blocking action of carvedilol should modify the pressure rise.
Commercial Packaging
Carvista 6.25 : Box containing 10 blister strips of 10 tablets.
Carvista 12.5 : Box containing 5 blister strips of 10 tablets.
Carvista 25 : Box containing 3 blister strips of 10 tablets.
Products from the same therapeutic group
Anti Anginal
Trimetazidine Dihydrochloride tablet
Ivabradine Hydrochloride
Ranolazine 500 mg
Nitroglycerin 2.6 mg Capsule & Tablet
Trocer Spray
Nitroglycerin 0.4 mg Spray
Anti Coagulant
Enoxaparin Sodium BP
Rivaroxaban 10 & 15 mg Tablet
Warfarin tablet
Anti Fibrinolytic
Tranexamic acid BP
Anti Hypertensive
ARB Plain
Losartan Potassium Tablet
Valsartan tablet
Olmesartan Medoxomil 20 mg Tablet
ACE Inhibitor Plain
Ramipril tablet
ACE Inhibitor Combination
Indapamide and Perindopril Erbumine
Ramoril Plus
Ramipril & Hydrochlorothiazide Tablet
Carvedilol 6.25, 12.5 & 25 mg tablet
Metoprolol tartrate
Bisoprolol Fumarate 2.5 & 5 mg Tablet
Calcium Channel Blocker
Lercanidipine Hydrochloride film-coated tablet
Verapamil hydrochloride
Amlodipine tablet
Centrally Acting Antihypertensive
Combined Antihypertensive Preparations
Amlodipine plus Atenolol tablet
Osartil Plus
Losartan Potassium & Hydrochlorothiazide Tablet
Amlodipine & Valsartan tablet
Valsartil Plus
Valsartan & Hydrochlorothiazide tablet
Xyotil Plus
Olmesartan Medoxomil plus Hydrochlorothiazide
Bisopro Plus
Bisoprolol fumarate and Hydrochlorothiazide tablet
Hydrochlorothiazide tablet
Frusemide & Spironolactone Tablet
Indapamide 1.5 mg Tablet
Eplerenone 25 mg Tablet
Spironolactone 25 mg Tablet
Anti Platelet
Eptifibatide INN
Clopidogrel tablet
Lopirel Plus
Clopidogrel & Aspirin Tablet
Prasugrel Hydrochloride INN tablet
Ticagrelor 90 mg Tablet
Lipid Lowering
Fenofibrate Capsule
Ridel  ER
Niacin USP 500 mg Extended Release tablet
Rosuvastatin 5 & 10 mg Tablet
Atorvastatin 10 mg and Amlodipine 5 mg
Atorvastatin 10, 20 & 40 mg tablet
Sympathomimetics / Inotropes
Adrenaline 1 mg/ml IV, IM, SC injection
Dobutamine Hydrochloride USP
Dopamine Hydrochloride BP Injection