Quiet 25: Each film coated tablet contains Quetiapine Fumarate INN 28.728 mg equivalent to 25 mg of Quetiapine.
Quiet 100: Each film coated tablet contains Quetiapine Fumarate INN 115.126 mg equivalent to 100 mg of Quetiapine.
The mechanism of action of Quetiapine is unknown. However, it has been proposed that this drug\\\'s efficacy in schizophrenia is mediated through a combination of dopamine D2 and serotonin 5HT2 antagonism. Quetiapine\\\'s antagonism of histamine H1 receptors may explain the somnolence and that of adrenergic a1 receptors may explain the orthostatic hypotension observed with this drug.
Elimination of Quetiapine is mainly via hepatic metabolism with a mean terminal half-life of about 6 hours. Steady-state concentrations are expected to be achieved within two days of dosing. Quetiapine is unlikely to interfere with the metabolism of drugs metabolized by cytochrome P450 enzymes.
Quetiapine Fumarate is rapidly absorbed after oral administration, reaching peak plasma concentrations in 1.5 hours. The tablet formulation is100% bioavailable relative to solution. The bioavailability of Quetiapine is marginally affected by administration with food, with Cmax and AUC values increased by 25% and 15%, respectively.It is 83% bound to plasma proteins at therapeutic concentrations. Following a single oral dose less than 1% of the administered dose is excreted as unchanged drug. Approximately 73% and 20% of the doses were recovered in the urine and feces, respectively. Quetiapine is extensively metabolized by the liver.
Quetiapine is indicated for the treatment of schizophrenia. Physician who elects to use Quetiapine for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient
As monotherapy or as adjunct therapy with other anti-psychotic drugs
1st 50 mg Twice daily
2nd 100 mg Twice daily
3rd 150 mg Twice daily
4th 200 mg Twice daily
5th 300 mg Twice daily
6th 400 mg Twice daily
Data indicates that the majority of patients responded between 400 to 800 mg/day. The safety of doses above 800 mg/day has not been evaluated in clinical trials.
Usual Dose: Quetiapine should generally be administered with an initial dose of 25 mg bid, with increments of 25-50 mg bid or tid on the second and third day, as tolerated, to a target dose range of 300 to 400 mg daily by the fourth day, given bid or tid. Further dosage adjustments, if indicated, should generally occur at intervals of not less than 2 days, as steady-state for Quetiapine would not be achieved for approximately 1-2 days in the typical patient. When dosage adjustments are necessary, dose increments/decrements of 25-50 mg bid are recommended. Most efficacy data with Quetiapine were obtained using tid regimens, but in one controlled trial 225 mg bid was also effective.
Pediatric Use: The safety and effectiveness of Quetiapine in pediatric patients less than 18 yrs have not been established
Nursing Mothers: It is recommended that women receiving Quetiapine should not breast feed.
Quiet 100: Each box contains 5 blister strips of 10 tablets.