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Tenaxit (Flupentixol & Melitracen)
Therapeutic Group: Drugs of Nervous System » Anti Depressant
Presentation
Tenaxit

Tenaxit tablet: Each tablet contains flupentixol dihydrochloride INN equivalent to 0.5 mg flupentixol and melitracen hydrochloride INN equivalent to 10 mg melitracen.

Descriptions
Tenaxit consists of two well known and well proven compounds: flupentixol- a neuroleptic with anxiolytic and antidepressant properties of its own when given in small doses, and melitracen - a bipolar thymoleptic with activating properties in low doses. In combination the compounds render a preparation with antidepressant, anxiolytic and activating properties.

Maximal serum concentration is reached in about 4 hours after oral administration of flupentixol and in about 4 hours after oral administration of melitracen. The biological half-life of flupentixol is about 35 hours and that of melitracen is about 19 hours. The combination of flupentixol and melitracen does not seem to influence the pharmacokinetic properties of the individual compounds.
Indications
Tenaxit is indicated in various types of anxiety, depression and apathy. These include-

* Psychogenic depression

* Depressive neuroses

* Masked depression

* Psychosomatic affections accompanied by anxiety and apathy

* Menopausal depressions

* Dysphoria and depression in alcoholics and drug-addicts
Dosage & Administration
Adults: Usually 2 tablets daily: morning and noon.
In severe cases the morning dose may be increased to 2 tablets.
Elderly patients: 1 tablet in the morning.
Maintenance dose: Usually 1 tablet in the morning. In cases of insomnia or severe restlessness additional treatment with sedative in the acute phase is recommended.
Side Effects
In the recommended doses side-effects are rare. These could be transient restlessness and insomnia.
Precautions
If previously the patient has been treated with tranquilizers with sedative effect these should be withdrawn gradually.
Contraindications
The immediate recovery phase after myocardial infarction. Defects in bundle-branch conduction. Untreated narrow angle glaucoma. Acute alcohol, barbiturate and opiate intoxications. Flupentixol-melitracen should not be given to patients who have received a MAO-inhibitor within two weeks. Not recommended for excitable or overactive patients since its activating effect may lead to exaggeration of these characteristics.
Use in Pregnancy & Lactation
Flupentixol-melitracen should preferably not be given during pregnancy and lactation.
Overdose
Symptoms: In cases of overdosage the symptoms of intoxications by melitracen, especially of anticholinergic nature, dominate. More rarely extrapyramidal symptoms due to flupentixol occur.
Treatment: Symptomatic and supportive. Gastric lavage should be carried out as soon as possible and activated charcoal may be administered. Measures aimed at supporting the respiratory and cardiovascular systems should be instituted. Epinephrine (adrenaline) must not be used for such patients. Convulsions may be treated with diazepam and extrapyramidal symptoms with biperiden.
Commercial Packaging
Tenaxit tablet: Each box contains 5 blister strips of 10 tablets.
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