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Siesta (Bromazepam)
Therapeutic Group: Drugs of Nervous System » Anxiolytic and Tranquilizer
Presentation
Siesta

Siesta: Each tablet contains Bromazepam USP 3 mg.

Descriptions
Siesta is a pyridylbenzodiazepine compound with anxiolytic properties. In low dosage, it diminishes anxiety, tension and nervousness. In high dosage, the sedative and muscle-relaxant properties appear.
Indications
Siesta is indicated in the following diseases:

* Emotional disturbances: Anxiety and tension states, as adjuvant therapy for anxiety in depressed patients, nervous tension, restlessness, and anxiety- and tension- related insomnia. As an adjuvant to treatment of underlying disease responsible for functional or psychosomatic impairments of various organs caused by anxiety and tension.

* Cardiovascular and respiratory systems: Pseudoangina pectoris, precordial anxiety, tachycardia, emotiogenic hypertension, dyspnea, and hyperventilation.

* Gastrointestinal tract: Irritable bowel syndrome, ulcerative colitis, epigastric pain, spasm, meteorism, and diarrhoea.

* Urogenital tract: Irritable bladder, urinary frequency and dysmenorrhea.

* Other psychosomatic disturbances: Psychogenic headache, psychogenic dermatoses.

Siesta is suitable for treatment of anxiety and tension states due to chronic organic disease and as an adjuvant to psychotherapy in psychoneurosis.
Dosage & Administration
Adults: The optimum dosage and frequency of administration of Bromazepam is based on the individual patient, the severity of symptoms and previous psychotropic drug history.
Average dose for outpatient therapy: 1.5 - 3 mg 3 times daily.
Severe cases, especially in hospitals: 6 - 12 mg 2 - 3 times daily.
Treatment of outpatients should begin with low doses, gradually increasing to the optimum level. In general, the total duration of treatment should not exceed 8-12 weeks including a tapering-off period. In certain cases, treatment may need to be continued beyond the maximum recommended duration but only after a careful reassessment of the patient's condition and indications.
Elderly patients: Doses should not exceed half those normally recommended.
Children: Bromazepam is not for paediatric use.
Side Effects
Common side effects include drowsiness, sedation, unsteadiness and ataxia. These are dose-related and may persist into the following day, even after a single dose. Other side effects are rare and include headache, vertigo, hypotension, gastrointestinal upsets, skin rashes, visual disturbances and urinary retention.
Precautions
In patients with chronic pulmonary insufficiency, and in patients with chronic renal or hepatic disease, dosage may need to be reduced.
Bromazepam should not be used alone to treat depression or anxiety associated with depression.
Bromazepam should be used with extreme caution in patients with a history of alcohol or drug abuse.
Contraindications
Bromazepam is contraindicated in patients with known hypersensitivity to benzodiazepines; severe respiratory failure, sleep apnea syndrome, myasthenia gravis and severe liver failure.
Use in Pregnancy & Lactation
Pregnancy: The safety of Bromazepam in pregnant women has not been established. Bromazepam should not be used during pregnancy, especially during the first and last trimesters, unless there are compelling reasons.
Lactation: Benzodiazepines have been detected in breast milk. If possible, the use of Bromazepam should be avoided during lactation.
Drug Interaction
If Bromazepam is combined with other centrally acting drugs, such as neuroleptics, tranquilizers, antidepressants, hypnotics, narcotic analgesics and anaesthetics, its CNS sedation effect may be increased.
Overdose
Manifestations of overdosage include somnolence, confusion, and respiratory and cardiovascular depression with coma in severe cases.
Commercial Packaging
Siesta: Each box contains 3 blister strips of 10 tablets.
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