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Rynex (Oxymetazoline)
Therapeutic Group: Respiratory » Drugs for Allergic Rhinitis » Nasal Decongestant & Mast Cell Combination

Rynex 0.05% Nasal Drop: Each ml contains 0.05 mg of Oxymetazoline Hydrochloride BP.

Rynex 0.025% Nasal Drop (For Children): Each ml contains 0.025 mg of Oxymetazoline Hydrochloride BP.

Rynex Nasal Spray: Each actuation delivers Oxymetazoline Hydrochloride BP 25 mcg.

Oxymetazoline Hydrochloride is an imidazoline derivative sympathomimetic amine. It directly stimulates alpha adrenergic receptors of the sympathetic nervous system. Intranasal application of oxymetazoline results in constriction of dilated arterioles and reduction in nasal blood flow and congestion.
Oxymetazoline Hydrochloride is applied topically to relieve nasal congestion associated with acute or chronic rhinitis, common cold, sinusitis, and hay fever or other allergies. It is also used as nasal decongestant in otitis media.
Dosage & Administration
Adults and children 6 yrs of age and older : 2-3 drops or sprays in each nostril twice daily for 3-5 days.
Children of age 2-6 : 2-3 drops in each nostril twice daily for 3-5 days. Sprays are generally unsuitable for young children because of the small size of their nostrils. The drug is not recommended in children under the age of 2.
Side Effects
* Transient burning, dryness of the nasal mucosa, sneezing.
* Nervousness, dizziness, headache.
* Hypertension, palpitation or reflex bradycardia.
* Prolonged use may result in rebound congestion.
* Since oxymetazoline has systemic adverse effects, it should be used with caution in patients with
* hypertension, cardiovascular disease or hyperthyroidism or in those receiving MAO inhibitors.
Contraindicated in patients hypersensitive to Oxymetazoine Hydrochloride.
Use in Pregnancy & Lactation
Pregnancy : Safe use of oxymetazoline during pregnancy has not been established; it should be avoided by pregnant women.
Nursing Mother : It is not known whether oxymetazoline is secreted in human breast milk; caution is advised.
Drug Interaction
Monoamine oxidase inhibitors (MAOIs): Concomitant use of oxymetazoline and MAOI can result in
hypertensive reaction. Tricyclic antidepressants (TCAs): TCAs may increase the effects of
oxymetazoline on blood pressure.
Following a proper application, systemic action is unlikely. If, however, some of the drops are swallowed, systemic effect can be produced. Symptoms include rapid, irregular heartbeat, headache, dizziness, increased sweating, nervousness. Such symptoms are more likely to be seen in young children.
Commercial Packaging
Rynex 0.05% Nasal Drop: Supplied in 10 ml plastic dropper bottle.
Rynex 0.025% Nasal Drop (For Children): Supplied in 10 ml plastic dropper bottle.
Rynex Nasal Spray: Each bottle contains 200 metered doses for spray.
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