Home > Twinvir
Share
Twinvir
Ledipasvir 90 mg & Sofosbuvir 400 mg

Presentation


Twinvir: Each tablet contains Ledipasvir INN 90 mg and Sofosbuvir INN 400 mg

Descriptions

It is a fixed-dose combination tablet containing Ledipasvir and Sofosbuvir for oral administration. Ledipasvir is an HCV NS5A inhibitor and Sofosbuvir is a nucleotide analog inhibitor of HCV NS5B polymerase.

Indications

Ledipasvir and Sofosbuvir combination is indicated for the treatment of chronic hepatitis C (CHC) genotype 1, 4 & 6 infection in adults.

Dosage & Administration

• Recommended dosage: One tablet (90 mg of Ledipasvir and 400 mg of Sofosbuvir) taken orally once daily with or without food
• Recommended treatment duration:
Treatment-naïve with or without cirrhosis: 12 weeks
• Treatment-experienced without cirrhosis: 12 weeks
• Treatment-experienced with cirrhosis: 24 weeks
A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease.

Side Effects

The most common adverse reactions with treatment with Ledipasvir and Sofosbuvir combination for 8, 12, or 24 weeks are fatigue and headache.

Precautions

• Bradycardia with Amiodarone coadministration: Serious symptomatic bradycardia may occur in patients taking Amiodarone, particularly in patients also receiving beta blockers, or those with underlying cardiac comorbidities and/or advanced liver disease. Coadministration of Amiodarone with Ledipasvir and Sofosbuvir combination is not recommended. In patients without viable treatment options, cardiac monitoring is recommended
• Use with other drugs containing sofosbuvir, is not recommended

Contraindications

None

Use in Pregnancy & Lactation

Pregnancy Category B
There are no adequate and well-controlled studies with Ledipasvir and Sofosbuvir combination in pregnant women.
Ledipasvir and Sofosbuvir combination should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
It is not known whether Ledipasvir and Sofosbuvir combination and its metabolites are present in human breast milk.

Well, the A-line prom dresses are certainly suitable for all women. It is a kind of neutral dress which is compatible for brides with all kinds of body shape such as big bottom or pear, apple, hourglass and even petite. Following the latest trend of bridal gown, strapless prom dresses uk are very famous among women. Basically, the strapless wedding dress involves sweetheart neckline cut to prettier the dress.

Pediatric Use
Safety and effectiveness of Ledipasvir and Sofosbuvir combination have not been established in pediatric patients

Drug Interaction

• Coadministration with amiodarone may result in serious symptomatic bradycardia. Use of Ledipasvir and Sofosbuvir combination with Amiodarone is not recommended
• P-gp inducers (e.g., Rifampin, St. John’s wort): May alter concentrations of Ledipasvir and Sofosbuvir. Use of Ledipasvir and Sofosbuvir combination with P-gp inducers is not recommended

Commercial Packaging

Twinvir Container Pack: Each bottles contains 28 tablets.
Twinvir Blister pack: Each box contains 1 blister strip of 6 tablets.

 

Other christian louboutin outlet collection comes in mermaid shoes cut. There are two samples of louboutin sneakers shown in the pictures. Both shoes are different indeed with stylish and creative details on certain areas such as skirt, waist and chest. To match the latest christian louboutin model, these mermaid cut wedding shoes a la princess of fairytale apply sweetheart strapless neckline cut. Thick ruffle details are applied on the first louboutin schuhe. The ruffle application is combined with pleated details on the louboutin shoes uk. Thus, in conclusion, the christian louboutin schuhe is extremely very marvelous for your modern fairytale bridal. Women always like louboutin. Sometimes, you will find louboutin damen schuhe online. But they are high quality louboutin schuhe deutschland. Best louboutin schuhe outlet for girls. The 1:1 christian louboutin are also perfect. Luxury louboutin schoenen for sale online.